Evidence map›Paper›PMID 21292654›Full record

GuidelineClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011

International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.

Kalpana Gupta, Thomas M Hooton, Kurt G Naber, Björn Wullt, Richard Colgan, Loren G Miller, Gregory J Moran, Lindsay E Nicolle, Raul Raz, Anthony J Schaeffer and 3 more

7 registry-linked trialsAbstract readPractice GuidelineReview
PubMed Publisher
In one paragraph

Guideline in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 1,231 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,231citing papers in PubMed, 3 pooled it
90.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03362697 nacompletednot on this mapstarted 2017, after this paper: background citation

Randomized Clinical Trial on the Safety and Efficacy of Lactobacillus Reuteri DSM 16666/ATCC 55845 & Lactobacillus Reuteri DSM 17938 for Treatment of Pregnant Women With Asymptomatic Bacteriuria or Uncomplicated Acute Cystitis

TypeinterventionalSponsorInnovacion y Desarrollo de Estrategias en SaludRan2017 to 2019Enrolled150ConditionsUrinary Tract Infection in PregnancyArmsProbiotics, Antibiotics
NCT03644966 nacompletednot on this mapstarted 2018, after this paper: background citation

Probiotic and Effects on Multi-Drug Resistant Urinary Tract Infection

TypeinterventionalSponsorOchsner Health SystemRan2018 to 2022Enrolled25ConditionsUrinary Tract Infections, Recurrent UTI, Antibiotic Resistant InfectionArmsBifidobacterium infantis, Placebo, Antibiotics
NCT04291768 phase4recruitingnot on this mapstarted 2020, after this paper: background citation

Short Course Antibiotic Treatment of Gram-negative Bacteremia: A Multicenter, Randomized, Non-blinded, Non-inferiority Interventional Study

TypeinterventionalSponsorThomas BenfieldRan2020 to 2026Enrolled380ConditionsGram-negative Bacteremia, Urinary Tract Infection BacterialArmsShortened antibiotic treatment, Standard antibiotic treatment
NCT05055544 naunknown statusnot on this mapstarted 2021, after this paper: background citation

BeaRberry in the Treatment of Acute UncoMplIcated Cystitis (BRUMI)- Protocol of a Multicentre, Randomized Double-Blind Clinical Trial

TypeinterventionalSponsorUniversity of PecsRan2021 to 2025Enrolled504ConditionsCystitisArmsFosfomycin, Bearberry
NCT06127160 phase4completednot on this mapstarted 2024, after this paper: background citation

Personalized Antibiotic Treatment in the Emergency Department: Panther Trial

TypeinterventionalSponsorBrett A FaineRan2024 to 2025Enrolled39ConditionsPyelonephritis AcuteArmsCephalexin, Cephalexin or placebo
NCT06387329 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Urinary Tract Infection Prophylaxis In Intradetrusor OnabotulinumtoxinA Procedures: A Randomized Controlled Trial

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2024 to 2025Enrolled100ConditionsOveractive Bladder, Bladder Pain SyndromeArmsNitrofurantoin 100 MG
NCT07407673 phase3not yet recruitingnot on this mapstarted 2027, after this paper: background citation

Prediction and Prevention of Bloodstream Infections After Kidney Transplantation - The PREDICT Study

TypeinterventionalSponsorSusanne Dam Nielsen, MD, DMScRan2027 to 2041Enrolled180ConditionsKidney Transplant Infection, Bloodstream Infection, Kidney Transplant, Kidney Transplant RecipientsArmsPivmecillinam, Placebo
3 · Its place in the literature

Who cites it

1,231 citing papers in PubMed, 3 syntheses or guidelines pooled it, 2,957 citations in OpenAlex.

  1. Management of acute pyelonephritis: a systematic review of oral versus single-dose intravenous followed by oral antibiotic treatment.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Pooled it
  2. Pooled it
  3. Safety and Tolerability of Pivmecillinam During More Than Four Decades of Clinical Experience: A Systematic Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Pooled it
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  9. Efficacy andAntimicrobial agents and chemotherapy · 2025
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  11. Efficacy andAntimicrobial agents and chemotherapy · 2025
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  14. Article
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  20. Comparison of oral third- versus first-/ second-generation cephalosporins for acute uncomplicated cystitis: a nationwide retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article

1,171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 5 countries.

Kalpana GuptaDepartment of Medicine, Veterans Affairs Boston Health Care System, Boston University School of Medicine, Boston, Massachusetts, USA. kalpana.gupta@va.gov
Thomas M Hooton
Kurt G Naber
Björn Wullt
Richard Colgan
Loren G Miller
Gregory J Moran
Lindsay E Nicolle
Raul Raz
Anthony J Schaeffer
David E Soper
Infectious Diseases Society of America
European Society for Microbiology and Infectious Diseases
Boston University · USEmek Medical Center · ILLund University · SEMedical University of South Carolina · USNorthwestern University · USOlive View-UCLA Medical Center · USTechnical University of Munich · DEUniversity of California, Los Angeles · USUniversity of Manitoba · CAUniversity of Maryland, Baltimore · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A Panel of International Experts was convened by the Infectious Diseases Society of America (IDSA) in collaboration with the European Society for Microbiology and Infectious Diseases (ESCMID) to update the 1999 Uncomplicated Urinary Tract Infection Guidelines by the IDSA. Co-sponsoring organizations include the American Congress of Obstetricians and Gynecologists, American Urological Association, Association of Medical Microbiology and Infectious Diseases-Canada, and the Society for Academic Emergency Medicine. The focus of this work is treatment of women with acute uncomplicated cystitis and pyelonephritis, diagnoses limited in these guidelines to premenopausal, non-pregnant women with no known urological abnormalities or co-morbidities. The issues of in vitro resistance prevalence and the ecological adverse effects of antimicrobial therapy (collateral damage) were considered as important factors in making optimal treatment choices and thus are reflected in the rankings of recommendations.

Indexed as

Acute DiseaseAnti-Bacterial AgentsBacteriaBacterial InfectionsCystitisDrug Resistance, BacterialFemaleHumansPyelonephritisAnti-Bacterial Agents

Identifiers

PMID21292654
OpenAlexW2120750073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.