ArticleHuman reproduction (Oxford, England)2011
The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotrophin.
Article in Human reproduction (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- The association of placental to fetal ratio with pregnancy duration.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Review
- First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies.Human reproduction update · 2021Review
- A toolkit for the application of placental-fetal molecular biomarkers in epidemiologic studies of the fetal origins of chronic disease.Current epidemiology reports · 2021Article
- Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells.Frontiers in cell and developmental biology · 2021Review
- Analgesic use at ovulation and implantation and human fertility.American journal of obstetrics and gynecology · 2020Article
- Smoke, alcohol and drug addiction and female fertility.Reproductive biology and endocrinology : RB&E · 2020Review
- Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation.Environmental health : a global access science source · 2019Article
- Fetal sex differences in human chorionic gonadotropin fluctuate by maternal race, age, weight and by gestational age.Journal of developmental origins of health and disease · 2015Article
- Human Chorionic Gonadotropin Partially Mediates Phthalate Association With Male and Female Anogenital Distance.The Journal of clinical endocrinology and metabolism · 2015Article
- Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes.PloS one · 2014Article
- Length of human pregnancy and contributors to its natural variation.Human reproduction (Oxford, England) · 2013Article
- Embryonic diapause in humans: time to consider?Reproductive biology and endocrinology : RB&E · 2013Article
- Natural selection in utero induced by mass layoffs: the hCG evidence.Evolutionary applications · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND Late implantation and the pattern of early rise in hCG have been associated with early pregnancy loss. We explored factors that might be predictive of these markers of poor embryonic health in spontaneously conceived pregnancies. METHODS Participants in the North Carolina Early Pregnancy Study collected daily first-morning urine specimens while attempting to conceive. Samples were assayed for estrogen and progesterone metabolites (to identify day of ovulation) and hCG (to detect conception). Data were available for 190 pregnancies, 48 of which ended in early loss (within 6 weeks of the last menstrual period). We used logistic regression to identify characteristics associated with late implantation (≥10 days post-ovulation). For pregnancies surviving at least 6 weeks (n= 142), we used linear mixed models to identify factors associated with variations in hCG rise in the first 7 days from detection. RESULTS Later implantation was associated with current maternal smoking [odds ratio (OR): 5.7; 95% confidence interval (CI): 1.1-30] and with oocytes that were likely to have been fertilized late in their post-ovulatory lifespan (OR: 5.1; CI: 1.9-16). Older women had a faster rise in hCG (P= 0.01), as did women who had relatively late menarche (P for trend = 0.02). Women exposed in utero to diethylstilbestrol showed an unusual pattern of slow initial hCG rise followed by a fast increase, a pattern significantly different from that of unexposed women (P= 0.002). CONCLUSIONS Although limited by small numbers and infrequent exposures, our analyses suggest that a woman's exposures both early in life and at the time of pregnancy may influence early development of the conceptus.
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Registered trials
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