Evidence map›Paper›PMID 21292540›Full record

ReviewCurrent opinion in chemical biology2011

Iron-containing transcription factors and their roles as sensors.

Angela S Fleischhacker, Patricia J Kiley

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Microbes vary strategically in their metalation of mononuclear enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Recent Advances in the Siderophore Biology ofFrontiers in microbiology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Angela S FleischhackerDepartment of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States.
Patricia J Kiley

Funding

The Regulation of Gene Expression by OxygenR01GM045844 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KILEY, PATRICIA J · 1991 to 2012
$4.4M
Studies of the regulation of IscR by [2Fe-2S] cluster bindingF32GM085987 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FLEISCHHACKER, ANGELA SUE · 2008 to 2010
$143k
NIGMS NIH HHS F32 GM085987NIGMS NIH HHS F32GM085987NIGMS NIH HHS GM45844NIGMS NIH HHS R01 GM045844
6 · The paper itself

Abstract

Iron-binding transcription factors are widespread throughout the bacterial world and to date are known to bind several types of cofactors, such as Fe2+, heme, or iron-sulfur clusters. The known chemistry of these cofactors is exploited by transcription factors, including Fur, FNR, and NsrR, to sense molecules such as Fe2+, gases (e.g. oxygen and nitric oxide), or reactive oxygen species. New structural data and information generated by genome-wide analysis studies have provided additional details about the mechanism and function of iron-binding transcription factors that act as sensors.

Indexed as

BacteriaBacterial ProteinsIronIron-Sulfur ProteinsNitric OxideOxygenTranscription FactorsBacterial ProteinsIronIron-Sulfur ProteinsNitric OxideOxygenTranscription Factors

Identifiers

PMID21292540
PMCPMC3074041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.