Evidence map›Paper›PMID 21292462›Full record

ReviewCurrent opinion in cell biology2011

Gene positioning and expression.

Defne Egecioglu, Jason H Brickner

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Defne EgeciogluDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Jason H Brickner

Funding

Role of DNA localization in regulating transcriptionR01GM080484 · NIGMS · NORTHWESTERN UNIVERSITY · PI BRICKNER, JASON HAYS · 2007 to 2019
$3.6M
NIGMS NIH HHS GM080484NIGMS NIH HHS R01 GM080484
6 · The paper itself

Abstract

Within the nucleus, the genome is spatially organized. Individual chromosomes are non-randomly positioned with respect to each other and with respect to nuclear landmarks [1,2]. Furthermore, the position of individual genes can reflect their expression. Here we discuss two well-characterized examples of gene relocalization associated with transcriptional activation: 1) developmentally regulated genes that move from the nuclear periphery to transcription factories in the nucleoplasm upon induction and 2) genes that are targeted from the nucleoplasm to the nuclear periphery, through interactions with the nuclear pore complex (NPC), upon activation. Finally, we speculate as to the mechanistic and functional commonalities of these phenomena.

Indexed as

Gene Expression RegulationGene OrderAnimalsCell NucleusChromosomesHumansNuclear PoreNuclear ProteinsTranscriptional ActivationNuclear Proteins

Identifiers

PMID21292462
PMCPMC3097288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.