ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2013
Genetic variability of human metapneumovirus amongst an all ages population in Cambodia between 2007 and 2009.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Genetic and epidemiological characteristics of the spread of human metapneumovirus in Bulgaria, 2023-2025.Frontiers in public health · 2026Article
- Molecular epidemiology and genetic diversity of human metapneumovirus among hospitalized children in Saudi Arabia during the COVID-19 era.BMC infectious diseases · 2025Article
- Actin cytoskeleton dynamics affect replication of human Metapneumovirus.Scientific reports · 2025Article
- Repeated introductions and widespread transmission of human metapneumovirus in Côte d'Ivoire.BMC infectious diseases · 2025Article
- The Burden of HMPV- and Influenza-Associated Hospitalizations in Adults in New Zealand Before and After the COVID-19 Pandemic, 2012-2023.The Journal of infectious diseases · 2025Article
- Prevalence of common respiratory viruses in children: insights from post-pandemic surveillance.BMC infectious diseases · 2025Article
- Human metapneumovirus (hMPV) in 2025: emerging trends and insights from community and hospital-based respiratory panel analyses-a comprehensive review.Virology journal · 2025Review
- Human metapneumovirus (hMPV): an associated etiology of severe acute respiratory infection in children of Eastern Uttar Pradesh, India.Access microbiology · 2024Article
- A decade of human metapneumovirus in hospitalized children with acute respiratory infection: molecular epidemiology in central Vietnam, 2007-2017.Scientific reports · 2023Article
- Burden of human metapneumovirus infections among children with acute respiratory tract infections attending a Tertiary Care Hospital, Kathmandu.BMC pediatrics · 2023Article
- Clinical characteristics and molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in China, 2017 to 2019: A multicentre prospective observational study.Virologica Sinica · 2022Observational
- Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua.Influenza and other respiratory viruses · 2022Article
- Molecular epidemiological surveillance of viral agents of acute lower respiratory tract infections in children in Accra, Ghana.BMC pediatrics · 2022Article
- Molecular investigation of human metapneumovirus in children with acute respiratory infections in Chennai, South India, from 2016-2018.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Molecular detection and genetic characterization of human metapneumovirus strains circulating in Islamabad, Pakistan.Scientific reports · 2022Article
- The Prevalence and Genetic Characterization of Human Metapneumovirus in Bulgaria, 2016-2019.Intervirology · 2021Article
- Epidemiological, clinical and genotypic features of human Metapneumovirus in patients with influenza-like illness in Senegal, 2012 to 2016.BMC infectious diseases · 2019Article
- Detection of six common human paramyxoviruses in patients with acute febrile respiratory symptoms using a novel multiplex real-time RT-PCR assay.Journal of medical virology · 2019Article
- Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017.PeerJ · 2019Article
- A multiplex one-tube nested real time RT-PCR assay for simultaneous detection of respiratory syncytial virus, human rhinovirus and human metapneumovirus.Virology journal · 2018Article
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Abstract
First identified in 2001, human metapneumovirus (HMPV) is a novel pathogen and causative agent of acute respiratory tract infection. Re-infection with HMPV is common, and currently there is no available vaccine against HMPV infection. Two genotypes of HMPV have been identified, A and B, both of which can be divided further into at least two distinct sub-genotypes. Here we report the results of the first study to investigate the genetic variability of HMPV strains circulating within Cambodia. The overall incidence of HMPV infection amongst an all-ages population of patients hospitalised with ALRI in Cambodia during 3 consecutive years, between 2007 and 2009, was 1.7%. The incidence of HMPV infection was highest amongst children less than 5 years of age, with pneumonia or bronchopneumonia the most frequent clinical diagnoses across all age groups. The incidence of HMPV infection varied annually. As anticipated, genetic diversity was low amongst the conserved F gene sequences but very high amongst G gene sequences, some strains sharing as little as 56.3% and 34.2% homology at the nucleotide and amino acid levels, respectively. Simultaneous co-circulation of strains belonging to the HMPV sub-genotypes B1, B2 and lineage A2b, amongst patients recruited at 2 geographically distinct provincial hospitals, was detected. Sub-genotype B2 strains were responsible for the majority of the infections detected, and a significant (p=0.013) association between infection with lineage A2b strains and disease severity was observed.
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