ArticleMolecular and cellular neurosciences2011
NG2 cells are uniformly distributed and NG2 is not required for barrel formation in the somatosensory cortex.
Article in Molecular and cellular neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning.Stem cell reports · 2026Article
- Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.Biomedicines · 2022Article
- The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Progenies of NG2 glia: what do we learn from transgenic mouse models ?Neural regeneration research · 2021Article
- Myelin plasticity in adulthood and aging.Neuroscience letters · 2020Review
- Review
- A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging.Nature neuroscience · 2017Article
- Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division.Nature neuroscience · 2014Article
- Distribution and phenotype of TrkB oligodendrocyte lineage cells in the adult rat spinal cord.Brain research · 2014Article
- Review
- Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization.Investigative ophthalmology & visual science · 2013Article
- NG2 cells in white matter but not gray matter proliferate in response to PDGF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Shaping barrels: activity moves NG2+ glia.Nature neuroscience · 2012Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The somatosensory barrel cortex in the rodent forms during the first postnatal week setting up a periphery related map with each whisker represented as a bundle of thalamocortical axons (TCAs) in layer IV. The centers of each barrel (hollows) contain the densely packed TCAs, while the areas between each barrel (septa) form a boundary between each barrel. NG2 chondroitin sulfate proteoglycan (CSPG) expressing cells (NG2 cells, polydendrocytes) make up a unique population of glial cells that receive synaptic like input and form close contacts with growing axons. In the present study we investigated the developmental distribution of NG2 cells in the barrel cortex to determine if they display preferential septa distribution similar to other extracellular and cell surface CSPGs. Immunohistochemistry for NG2 and platelet-derived growth factor receptor alpha (PDGFRα) in NG2DsRedBAC transgenic mice showed uniform distribution of NG2 cells and processes in barrel hollows and septa at postnatal (P) days 5, 6, 7, 8, 14, and 30. Changes in the barrel pattern formation caused by cauterization of one row of whiskers at P1 resulted in corresponding changes in extracellular and cell surface CSPG distribution at P7 but no detectable changes in NG2 cell bodies and processes. Furthermore, no abnormalities in barrel formation or reorganization were detected in NG2 knockout mice. These observations suggest that NG2 cells are unlikely to play an inhibitory boundary role on TCA growth and that NG2 expression is not necessary for normal barrel formation.
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