ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2011
Insular volume reduction in fragile X syndrome.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Brain volumes in genetic syndromes associated with mTOR dysregulation: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Brief intensive social gaze training reorganizes functional brain connectivity in boys with fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Extreme capsule is a bottleneck for ventral pathway.IBRO neuroscience reports · 2021Review
- Glucocorticoid regulation and neuroanatomy in fragile x syndrome.Journal of psychiatric research · 2021Article
- Neuroanatomical abnormalities in fragile X syndrome during the adolescent and young adult years.Journal of psychiatric research · 2018Article
- Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder.Annals of behavioral neuroscience · 2018Article
- Altered Brain Network Segregation in Fragile X Syndrome Revealed by Structural Connectomics.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Moving Toward Integrative, Multidimensional Research in Modern Psychiatry: Lessons Learned From Fragile X Syndrome.Biological psychiatry · 2016Review
- Molecular medicine of fragile X syndrome: based on known molecular mechanisms.World journal of pediatrics : WJP · 2016Review
- Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons.Brain : a journal of neurology · 2015Article
- Fear-specific amygdala function in children and adolescents on the fragile x spectrum: a dosage response of the FMR1 gene.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Insular cortex abnormalities in psychotic major depression: relationship to gender and psychotic symptoms.Neuroscience research · 2013Article
- Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations.The International journal of neuroscience · 2012Review
- What can we learn about autism from studying fragile X syndrome?Developmental neuroscience · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Fragile X syndrome (FraX) is the most common form of inherited mental deficit and is caused by mutations of the Fragile X Mental Retardation 1 (FMR1) gene on the X chromosome. While males and females with the full FMR1 mutation are affected differently because the disorder is X-linked, both suffer from varying degrees of cognitive impairment, attention deficits and social anxiety. The insula is a sensory integrative region that has been increasingly suggested as a critical area involved in anxiety manifestation. The current study was designed to examine possible changes in insular volume in FraX compared to age- and gender-matched typically developing healthy controls (HC) as well as age-, gender-, and intelligence-matched developmentally delayed controls (DD). An established native-space, manual morphometry method was utilized to quantify total and regional insular volumes using structural magnetic resonance imaging. Total, anterior and posterior insular volumes were found to be reduced in FraX compared to both HC and DD. The current data add to a growing literature concerning brain abnormalities in FraX and suggests that significant volume reduction of the insula is a component of the FraX neuroanatomical phenotype. This finding also provides an intriguing potential neural correlate for hyperarousal and gaze aversion, which are prominent behavioral symptoms of FraX.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.