ArticleCritical care (London, England)2011
Hormonal status in protracted critical illness and in-hospital mortality.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Association of thyroid hormones and thyroid-stimulating hormone with mortality in adults admitted to the intensive care unit: A systematic review and meta-analysis.Journal of the Chinese Medical Association : JCMA · 2022Pooled it
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- Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles.Critical care (London, England) · 2025Review
- Critical illness and sex hormones: response and impact of the hypothalamic-pituitary-gonadal axis.Therapeutic advances in endocrinology and metabolism · 2025Review
- Association between serum TSH levels and all-cause mortality in critically ill patients.Heliyon · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Opposite Effect of Thyroid Hormones on Oxidative Stress and on Mitochondrial Respiration in COVID-19 Patients.Antioxidants (Basel, Switzerland) · 2022Article
- Nonthyroidal Illness Syndrome: To Treat or Not to Treat? Have We Answered the Question? A Review of Metanalyses.Frontiers in endocrinology · 2022Review
- Frailty subtypes and recovery in older survivors of acute respiratory failure: a pilot study.Thorax · 2021Article
- Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.Burns & trauma · 2019Review
- High Prolactin Level as a Predictor of Vasospasm in Aneurysmal Subarachnoidal Hemorrhage.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2016Observational
- Frailty in Pulmonary and Critical Care Medicine.Annals of the American Thoracic Society · 2016Review
- Neither Single nor a Combination of Routine Laboratory Parameters can Discriminate between Gram-positive and Gram-negative Bacteremia.Scientific reports · 2015Article
- The prevalence of sarcopenia in patients with respiratory failure classified as normally nourished using computed tomography and subjective global assessment.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- Exploitation of diagnostic computed tomography scans to assess the impact of nutrition support on body composition changes in respiratory failure patients.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- Critical care nephrology: could it be a model of multidisciplinarity in ICU nowadays for other sub-specialities - the jury is out.International journal of nephrology and renovascular disease · 2014Review
- Pituitary deficiency after aneurysmal subarachnoid hemorrhage.Clinics (Sao Paulo, Brazil) · 2013Article
- Burn injury induces high levels of phosphorylated insulin-like growth factor binding protein-1.International journal of burns and trauma · 2013Article
- Relationship between thyroid function and ICU mortality: a prospective observation study.Critical care (London, England) · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to determine the relationship between hormonal status and mortality in patients with protracted critical illness.
methodsWe conducted a prospective observational study in four medical and surgical intensive care units (ICUs). ICU patients who regained consciousness after 7 days of mechanical ventilation were included. Plasma levels of insulin-like growth factor 1 (IGF-1), prolactin, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS) and cortisol were measured on the first day patients were awake and cooperative (day 1). Mean blood glucose from admission to day 1 was calculated.
resultsWe studied 102 patients: 65 men and 37 women (29 of the women were postmenopausal). Twenty-four patients (24%) died in the hospital. The IGF-1 levels were higher and the cortisol levels were lower in survivors. Mean blood glucose was lower in women who survived, and DHEA and DHEAS were higher in men who survived.
conclusionsThese results suggest that, on the basis of sex, some endocrine or metabolic markers measured in the postacute phase of critical illness might have a prognostic value.
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