ArticleEnvironmental science & technology2011
Species-specific differences and structure-activity relationships in the debromination of PBDE congeners in three fish species.
Article in Environmental science & technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.
- Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study.International journal of environmental research and public health · 2017Pooled it
- Review
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Evidence for reproductive health effects following exposure to hydraulic fracturing chemical mixtures.Reproduction (Cambridge, England) · 2024Review
- Article
- Patterns and Trends of Polybrominated Diphenyl Ethers in Bald Eagle Nestlings in Minnesota and Wisconsin, USA.Environmental toxicology and chemistry · 2021Article
- Environmental factors in debromination activity of polybrominated diphenyl ethers by hepatic microsomes of freshwater fish.Environmental science and pollution research international · 2021Article
- First assessment of POPs and cytochrome P450 expression in Cuvier's beaked whales (Ziphius cavirostris) skin biopsies from the Mediterranean Sea.Scientific reports · 2020Article
- A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity.Molecules (Basel, Switzerland) · 2020Review
- Halogen Bonding from the Bonding Perspective with Considerations for Mechanisms of Thyroid Hormone Activation and Inhibition.New journal of chemistry = Nouveau journal de chimie · 2018Article
- Water quality assessment in the "German River of the years 2014/2015": how a case study on the impact of a storm water sedimentation basin displayed impairment of fish health in the Argen River (Southern Germany).Environmental sciences Europe · 2017Article
- Emerging and priority contaminants with endocrine active potentials in sediments and fish from the River Po (Italy).Environmental science and pollution research international · 2015Article
- Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers.Chemical research in toxicology · 2015Article
- Bioaccumulation of dioxin-like PCBs and PBDEs by detritus-feeding fish in the Rio de la Plata estuary, Argentina.Environmental science and pollution research international · 2015Article
- Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels.Ecotoxicology (London, England) · 2015Article
- Effects of dietary exposure to brominated flame retardant BDE-47 on thyroid condition, gonadal development and growth of zebrafish.Fish physiology and biochemistry · 2013Article
- Low level exposure to the flame retardant BDE-209 reduces thyroid hormone levels and disrupts thyroid signaling in fathead minnows.Environmental science & technology · 2013Article
- PBDEs in leachates from municipal solid waste dumping sites in tropical Asian countries: phase distribution and debromination.Environmental science and pollution research international · 2013Article
- Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Species specific differences in the in vitro metabolism of the flame retardant mixture, Firemaster® BZ-54.Aquatic toxicology (Amsterdam, Netherlands) · 2012Article
- In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues.Chemical research in toxicology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have suggested that there may be species-specific differences in the metabolism of polybrominated diphenyl ethers (PBDEs) among different fish species. In this study, we investigated the in vitro hepatic metabolism of eleven individual PBDE congeners (tri- through decaBDEs) in three different fish species: rainbow trout (Oncorhynchus mykiss), common carp (Cyprinus carpio), and Chinook salmon (O. tschwatcha). In addition, we evaluated the influence of PBDE structural characteristics (i.e., bromine substitution patterns) on metabolism. Six of the eleven congeners we evaluated, BDEs 99, 153, 183, 203, 208, and 209, were metabolically debrominated to lower brominated congeners. All of the congeners that were metabolized contained at least one meta-substituted bromine. Metabolites were not detected for congeners without one meta-substituted bromine (e.g., BDEs 28, 47, and 100). Metabolite formation rates were generally 10 to 100 times faster in carp than in trout and salmon. BDEs 47, 49, 101, 154, and 183 were the major metabolites observed in all three species with the exception of BDE 47, which was only detected in carp. Carp demonstrated a preference toward meta-debromination, while trout and salmon debrominated meta- and para-bromine atoms to an equal extent. We compared glutathione-S-transferase (GST) and deiodinase (DI) activity among all three species as these enzyme systems have been hypothesized to play a role in PBDE debromination in teleosts. Carp exhibited a preference for meta-deiodination of the thyroid hormone thyroxine, which was consistent with the preference for meta-debromination of PBDEs observed in carp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.