Evidence map›Paper›PMID 21290221›Full record

ReviewHandbook of experimental pharmacology2011

Animal models of stress urinary incontinence.

Hai-Hong Jiang, Margot S Damaser

Open access · greenAbstract readReview
In one paragraph

Review in Handbook of experimental pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hai-Hong JiangBiomedical Engineering Department, The Cleveland Clinic, Cleveland, OH, 44195, USA.
Margot S Damaser
Cleveland Clinic · US

Funding

MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSIONR01HD038679 · NICHD · LOYOLA UNIVERSITY CHICAGO · PI DAMASER, MARGOT S. · 2000 to 2010
$2.7M
Stem Cell Homing for Treatment of Female Pelvic Floor DisordersR01HD059859 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI DAMASER, MARGOT S. · 2010 to 2014
$1.6M
NICHD NIH HHS R01 HD038679NICHD NIH HHS R01 HD059859
6 · The paper itself

Abstract

Stress urinary incontinence (SUI) is a common health problem significantly affecting the quality of life of women worldwide. Animal models that simulate SUI enable the assessment of the mechanism of risk factors for SUI in a controlled fashion, including childbirth injuries, and enable preclinical testing of new treatments and therapies for SUI. Animal models that simulate childbirth are presently being utilized to determine the mechanisms of the maternal injuries of childbirth that lead to SUI with the goal of developing prophylactic treatments. Methods of assessing SUI in animals that mimic diagnostic methods used clinically have been developed to evaluate the animal models. Use of these animal models to test innovative treatment strategies has the potential to improve clinical management of SUI. This chapter provides a review of the available animal models of SUI, as well as a review of the methods of assessing SUI in animal models, and potential treatments that have been tested on these models.

Indexed as

Disease Models, AnimalAnimalsHumansReproducibility of ResultsSpecies SpecificityUrinary BladderUrinary Incontinence, StressUrodynamics

Identifiers

PMID21290221
PMCPMC3218560
OpenAlexW1922672305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.