ArticleEuropean archives of psychiatry and clinical neuroscience2011
BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects.
Article in European archives of psychiatry and clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Pooled it
- Relationship between BDNF rs6265 (VAL66MET) polymorphism and serum BDNF LEVELS in anxiety disorders.Molecular biology reports · 2026Article
- A potential role for BDNF in recognition behavior revealed through knockout in zebrafish.Frontiers in behavioral neuroscience · 2026Article
- Circulating Growth Factors and Cytokines Correlate with Temperament and Character Dimensions in Adolescents with Mood Disorders.Brain sciences · 2025Article
- Investigation of the relationship between neuroplasticity and grapheme-color synesthesia.Frontiers in neuroscience · 2024Article
- The relevance of BDNF for neuroprotection and neuroplasticity in multiple sclerosis.Frontiers in neurology · 2024Review
- Biological effects of exposure to 2650 MHz electromagnetic radiation on the behavior, learning, and memory of mice.Brain and behavior · 2023Article
- The Relationship Among BDNF Val66Met Polymorphism, Plasma BDNF Level, and Trait Anxiety in Chinese Patients With Panic Disorder.Frontiers in psychiatry · 2022Article
- Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
- Plasma Brain-Derived Neurotropic Factor Levels Are Associated with Aging and Smoking But Not with Future Dementia in the Rotterdam Study.Journal of Alzheimer's disease : JAD · 2021Article
- Association of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with Body Mass Index, Fasting Glucose Levels and Lipid Status in Adolescents.Balkan journal of medical genetics : BJMG · 2020Article
- BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders.Aging and disease · 2018Review
- Cerebellar BDNF Promotes Exploration and Seeking for Novelty.The international journal of neuropsychopharmacology · 2018Article
- No gene-by-environment interaction of BDNFEuropean journal of psychotraumatology · 2018Article
- Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression.Molecular psychiatry · 2017Article
- Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer.Journal of affective disorders · 2016Article
- Serum BDNF levels before and after the development of mood disorders: a case-control study in a population cohort.Translational psychiatry · 2016Article
- Serum brain-derived neurotrophic factor levels and personality traits in patients with major depression.BMC psychiatry · 2015Article
- The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: a longitudinal study.PloS one · 2014Article
- Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress.Neuropsychiatric disease and treatment · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consisting evidence in animal models has suggested that alterations in brain-derived neurotrophic factor (BDNF) brain expression and release are involved in the pathogenesis of mental illnesses, such as, mood, anxiety, and eating disorders. This hypothesis is supported by data emerging from biochemical studies on serum BDNF levels and genetic studies on the functional polymorphism Val66Met in the BDNF gene in patients and control subjects. Anxiety-related personality traits are associated with several mental disorders. However, they are also measurable in non-affected subjects and, so, may represent a useful "endophenotype" to study the biological correlation of the vulnerability factors in the general population. In this study, we analyzed putative correlations in subjects unaffected by mental disorders between personality traits, serum BDNF levels (N = 107), and the BDNF Val66Met genotype (N = 217). Furthermore, we tested the possible interactions between these variables. A significant correlation has been observed between high scores of harm avoidance (HA) measured by the temperament and character inventory (TCI), and low BDNF serum concentration (r = -0.253, P = 0.009). In addition, an association has been evidenced between low BDNF levels in serum and the BDNF Val/Val genotype (P = 0.021). By analyzing putative concomitant effects of different variables on HA scores in a regression model, we observed a significant correlation only with BDNF serum concentrations (P = 0.022). The study results suggest that a decrease in serum BDNF concentrations may represent a biochemical marker associated with anxiety personality traits also retrievable in the general population.
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