ArticlePediatric surgery international2011
Therapeutic effects of vitamin A on experimental cholestatic rats with hepatic fibrosis.
Article in Pediatric surgery international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Serum Liposoluble Vitamins (A, D, E) in Dogs with Chronic Biliary Tract Diseases Versus Healthy Dogs.Veterinary sciences · 2025Article
- The relationship between blood vitamin A levels and diabetic retinopathy: a population-based study.Scientific reports · 2024Article
- Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling.Cell reports · 2023Article
- Retinoids in the Pathogenesis and Treatment of Liver Diseases.Nutrients · 2022Review
- Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model.Scientific reports · 2021Article
- The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- Article
- In vitro inhibition of hepatic stellate cell activation by the autophagy-related lipid droplet protein ATG2A.Scientific reports · 2018Article
- Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface.Annals of gastroenterology · 2017Review
- Vitamin A supplementation modifies the antioxidant system in rats.Nutrition research and practice · 2016Article
- Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.PloS one · 2015Article
- Advances in hepatic stem/progenitor cell biology.EXCLI journal · 2015Review
- The Sea Lamprey as an Etiological Model for Biliary Atresia.BioMed research international · 2015Review
- Interspecies comparison of stellate cell-containing macula flavae and vitamin A storage in vocal fold mucosa.Journal of anatomy · 2014Article
- Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation.Oxidative medicine and cellular longevity · 2014Article
- FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.Genes & development · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to investigate the role of hepatic stellate cells (HSCs) and the effect of vitamin A administration on liver damage induced by bile duct ligation (BDL) and administration of CCl(4).
methodsTwo types of animal model were used; one was BDL as a model of biliary atresia, the other was CCl(4)-induced hepatic fibrosis. Pathological changes of the liver with or without administration of vitamin A were compared by light and electron microscopy with focusing on HSCs in each experimental group. Immunohistochemical examination was performed with anti-keratinocyte growth factor (KGF), anti-alpha-smooth muscle actin (α-SMA), and anti-glial fibrillary acidic protein (GFAP) antibodies, as markers of fibrosis.
resultsOn light microscopic findings, periportal inflammation with bile ductular proliferation was obvious in BDL group and pericentral necrosis with fatty degeneration was observed in CCl(4) group, both of which were ameliorated by subcutaneous injection of vitamin A. Electron microscopy showed lipid droplets were almost depleted in the HSCs treated with BDL or CCl(4), which improved with vitamin A administration. Immunohistochemistry demonstrated that enhanced expression of all three fibrotic markers in the BDL group was diminished by vitamin A administration.
conclusionsAlthough most of our data are qualitative observation, vitamin A may ameliorate hepatic fibrosis in the BDL model by restoring vitamin A in the HSCs.
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