Evidence map›Paper›PMID 21290032›Full record

ReviewChemical Society reviews2011

Fluorescent DNA-based enzyme sensors.

Nan Dai, Eric T Kool

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 163 citations in OpenAlex.

  1. Article
  2. Review
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  7. A New Variant of Emissive RNA Alphabets.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  8. Article
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  10. Article
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  12. Review
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  17. Article
  18. Article
  19. Selective fluorogenic chemosensors for distinct classes of nucleases.Chembiochem : a European journal of chemical biology · 2013
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nan DaiDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Eric T Kool
Stanford University · US

Funding

Templated Chemistry for RNA AnalysisR01GM068122 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2003 to 2016
$3.5M
POLYFLUOROPHORES ASSEMBLED ON A DNA SCAFFOLDR01GM067201 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2003 to 2011
$2.2M
NIGMS NIH HHS GM067201NIGMS NIH HHS GM068122NIGMS NIH HHS R01 GM067201NIGMS NIH HHS R01 GM068122
6 · The paper itself

Abstract

Fluorescent sensors that make use of DNA structures have become widely useful in monitoring enzymatic activities. Early studies focused primarily on enzymes that naturally use DNA or RNA as the substrate. However, recent advances in molecular design have enabled the development of nucleic acid sensors for a wider range of functions, including enzymes that do not normally bind DNA or RNA. Nucleic acid sensors present some potential advantages over classical small-molecule sensors, including water solubility and ease of synthesis. An overview of the multiple strategies under recent development is presented in this critical review, and expected future developments in microarrays, single molecule analysis, and in vivo sensing are discussed (160 references).

Indexed as

Base SequenceBiosensing TechniquesDNAEnzymesFluorescent DyesHeLa CellsHumansMolecular Sequence DataDNAEnzymesFluorescent Dyes

Identifiers

PMID21290032
PMCPMC5575859
OpenAlexW2151986547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.