ArticleInternational journal of nanomedicine2011
Association between dental pulp stones and calcifying nanoparticles.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Clinical implications of calcifying nanoparticles in dental diseases: a critical review.International journal of nanomedicine · 2014Pooled it
- Association between diabetes and pulp stone prevalence and morphological characteristics: a CBCT-based retrospective study.BMC oral health · 2026Observational
- Prevalence of Pulp Stones on Panoramic Radiographs in Patients with Chronic Systemic Diseases: A Cross-sectional Study.Rambam Maimonides medical journal · 2025Article
- New Middle Pleistocene Hominin Dental Remains From Velika Balanica, Serbia.American journal of biological anthropology · 2025Article
- Segmentation of Pulp and Pulp Stones with Automatic Deep Learning in Panoramic Radiographs: An Artificial Intelligence Study.Dentistry journal · 2025Article
- Mechanism of influence of calcified nanoparticles in the development of calcified diseases (Review).Biomedical reports · 2025Review
- Cone-Beam Computed Tomography Assessment of the Prevalence and Association of Pulp Calcification with Dental and Periodontal Pathology: A Descriptive Study.Journal of clinical medicine · 2025Article
- A preliminary study on calcifying nanoparticles in dental plaque: Isolation, characterization, and potential mineralization mechanism.Clinical and experimental dental research · 2024Article
- Prevalence of Pulp Stones in the Population of Rajasthan: A Cross-Sectional Study in a Tertiary Care Hospital.Cureus · 2024Article
- A systematic review assessing the dental pulp stone prevalence in the Saudi Arabian population.The Saudi dental journal · 2023Review
- Article
- Effects of Orthodontic Treatment on Pulp Stone Formation: A Retrospective Study.BioMed research international · 2023Article
- Association between Periodontitis and Pulp Calcifications: Radiological Study.International journal of dentistry · 2022Article
- Pulp Stones: Diagnostic Significance in Early Diagnosis and Radiographic Correlation with Ischemic Heart Diseases.The Indian journal of radiology & imaging · 2021Article
- Assessing the Prevalence and Association of Pulp Stones with Cardiovascular Diseases and Diabetes Mellitus in the Saudi Arabian Population-A CBCT Based Study.International journal of environmental research and public health · 2020Article
- Pulp Stones as Risk Predictors for Coronary Artery Disease.International journal of preventive medicine · 2020Article
- Sialometric and Sialochemical Analysis in Individuals With Pulp Stones.Frontiers in cell and developmental biology · 2020Article
- Radiographic Assessment of the Prevalence of Pulp Stones in a Yemeni Population Sample.European endodontic journal · 2017Article
- The relationship between pulp calcifications and salivary gland calcifications.Journal of clinical and experimental dentistry · 2014Article
- Incidence and distribution of pulp stones found in radiographic dental examination of adult Turkish dental patients.Annals of medical and health sciences research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of dental pulp stones, one type of extraskeletal calcification disease, remains elusive to date. Calcifying nanoparticles (CNPs), formerly referred to as nanobacteria, were reported to be one etiological factor in a number of extraskeletal calcification diseases. We hypothesized that CNPs are involved in the calcification of the dental pulp tissue, and therefore investigated the link between CNPs and dental pulp stones. Sixty-five freshly collected dental pulp stones, each from a different patient, were analyzed. Thirteen of the pulp stones were examined for the existence of CNPs in situ by immunohistochemical staining (IHS), indirect immunofluorescence staining (IIFS), and transmission electron microscope (TEM). The remaining 52 pulp stones were used for isolation and cultivation of CNPs; the cultured CNPs were identified and confirmed via their shape and growth characteristics. Among the dental pulp stones examined in situ, 84.6% of the tissue samples staines positive for CNPs antigen by IHS; the corresponding rate by IIFS was 92.3 %. In 88.2% of the cultured samples, CNPs were isolated and cultivated successfully. The CNPs were visible under TEM as 200-400 nm diameter spherical particles surrounded by a compact crust. CNPs could be detected and isolated from a high percentage of dental pulp stones, suggesting that CNPs might play an important role in the calcification of dental pulp.
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