ArticleInternational journal of nanomedicine2010
Selective axonal growth of embryonic hippocampal neurons according to topographic features of various sizes and shapes.
Article in International journal of nanomedicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- The Future of Biohybrid Regenerative Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Feedback-controlled dynamics of neuronal cells on directional surfaces.Biophysical journal · 2022Article
- A Multiscale Model to Predict Neuronal Cell Deformation with Varying Extracellular Matrix Stiffness and Topography.Cellular and molecular bioengineering · 2020Article
- Coating Topologically Complex Electrospun Fibers with Nanothin Silk Fibroin Enhances Neurite Outgrowth in Vitro.ACS biomaterials science & engineering · 2020Article
- Recent advances in nanotherapeutic strategies for spinal cord injury repair.Advanced drug delivery reviews · 2019Review
- Modulating physical, chemical, and biological properties in 3D printing for tissue engineering applications.Applied physics reviews · 2018Article
- A closer look at neuron interaction with track-etched microporous membranes.Scientific reports · 2018Article
- Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.Biomedical materials (Bristol, England) · 2018Article
- Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2018Article
- Intracellular calcium and cyclic nucleotide levels modulate neurite guidance by microtopographical substrate features.Journal of biomedical materials research. Part A · 2016Article
- Production of Highly Aligned Collagen Scaffolds by Freeze-drying of Self-assembled, Fibrillar Collagen Gels.ACS biomaterials science & engineering · 2016Article
- Material and mechanical factors: new strategy in cellular neurogenesis.Neural regeneration research · 2014Review
- Label-free characterization of emerging human neuronal networks.Scientific reports · 2014Article
- Effects of surface asymmetry on neuronal growth.PloS one · 2014Article
- Neural responses to electrical stimulation on patterned silk films.Journal of biomedical materials research. Part A · 2013Article
- Superimposed topographic and chemical cues synergistically guide neurite outgrowth.Lab on a chip · 2013Article
- Micro-structural geometry of thin films intended for the inner lumen of nerve conduits affects nerve repair.Journal of materials science. Materials in medicine · 2013Article
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- New perspectives on neuronal development via microfluidic environments.Trends in neurosciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeUnderstanding how surface features influence the establishment and outgrowth of the axon of developing neurons at the single cell level may aid in designing implantable scaffolds for the regeneration of damaged nerves. Past studies have shown that micropatterned ridge-groove structures not only instigate axon polarization, alignment, and extension, but are also preferred over smooth surfaces and even neurotrophic ligands.
methodsHere, we performed axonal-outgrowth competition assays using a proprietary four-quadrant topography grid to determine the capacity of various micropatterned topographies to act as stimuli sequestering axon extension. Each topography in the grid consisted of an array of microscale (approximately 2 μm) or submicroscale (approximately 300 nm) holes or lines with variable dimensions. Individual rat embryonic hippocampal cells were positioned either between two juxtaposing topographies or at the borders of individual topographies juxtaposing unpatterned smooth surface, cultured for 24 hours, and analyzed with respect to axonal selection using conventional imaging techniques.
resultsTopography was found to influence axon formation and extension relative to smooth surface, and the distance of neurons relative to topography was found to impact whether the topography could serve as an effective cue. Neurons were also found to prefer submicroscale over microscale features and holes over lines for a given feature size.
conclusionThe results suggest that implementing physical cues of various shapes and sizes on nerve guidance conduits and other advanced biomaterial scaffolds could help stimulate axon regeneration.
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