ArticleDiabetes care2011
Hemoglobin A1c as a predictor of incident diabetes.
Article in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2017Pooled it
- Strawberries Improve Insulin Resistance and Related Cardiometabolic Markers in Adults with Prediabetes: A Randomized Controlled Crossover Trial.The Journal of nutrition · 2025Trial
- Association Between Delayed Metabolic and Bariatric Surgery Completion and Postoperative Cardiometabolic Outcomes.Obesity surgery · 2026Article
- Glycated albumin and composite glycemic-lipid indices: complementary tools for type 2 diabetes diagnosis.Journal of biomedical research · 2025Article
- Article
- Point-of-care capillary HbA1c measurement in the emergency department: a useful tool to detect unrecognized and uncontrolled diabetes.International journal of emergency medicine · 2016Article
- Incidence of type 2 diabetes in pre-diabetic Japanese individuals categorized by HbA1c levels: a historical cohort study.PloS one · 2015Article
- Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Review
- Using hemoglobin A1C as a predicting model for time interval from pre-diabetes progressing to diabetes.PloS one · 2014Article
- Metabolic syndrome and its components among obese (BMI >=95th) Mexican adolescents.Endocrine connections · 2013Article
- Development of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6).Diabetologia · 2012Article
- Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth.Diabetes care · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveSeveral studies have suggested that HbA(1c) levels may predict incident diabetes. With new recommendations for use of HbA(1c) in diagnosing diabetes, many patients with HbA(1c) results below the diagnostic threshold will be identified. Clinicians will need to categorize risk for a subsequent diabetic diagnosis in such patients. The objective of this study was to determine the ability of HbA(1c) to predict the incidence of a diabetic diagnosis. RESEARCH DESIGN AND
methodsWe performed a historical cohort study using electronic medical record data from two Department of Veterans Affairs Medical Centers. Patients (n = 12,589) were identified with a baseline HbA(1c) <6.5% between January 2000 and December 2001 and without a diagnosis of diabetes. Patients (12,375) had at least one subsequent follow-up visit. These patients were tracked for 8 years for a subsequent diagnosis of diabetes.
resultsDuring an average follow-up of 4.4 years, 3,329 (26.9%) developed diabetes. HbA(1c) ≥ 5.0% carried a significant risk for developing diabetes during follow-up. When compared with the reference group (HbA(1c) <4.5%), HbA(1c) increments of 0.5% between 5.0 and 6.4% had adjusted odds ratios of 1.70 (5.0-5.4%), 4.87 (5.5-5.9%), and 16.06 (6.0-6.4%) (P < 0.0001). Estimates of hazard ratios similarly showed significant increases for HbA(1c) ≥ 5.0%. A risk model for incident diabetes within 5 years was developed and validated using HbA(1c), age, BMI, and systolic blood pressure.
conclusionsThe incidence of diabetes progressively and significantly increased among patients with an HbA(1c) ≥ 5.0%, with substantially expanded risk for those with HbA(1c) 6.0-6.4%.
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