ArticleJournal of the American Society of Nephrology : JASN2011
Predominance of intraglomerular T-bet or GATA3 may determine mechanism of transplant rejection.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Triptolide-mediated immunomodulation of macrophages: from pathophysiology to therapy.Annals of medicine · 2025Review
- Programmed T cell differentiation: Implications for transplantation.Cellular immunology · 2020Review
- Characterization of eomesodermin and T-bet expression by allostimulated CD8Clinical and experimental immunology · 2018Article
- Transplant glomerulopathy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Review
- Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene.Internal medicine (Tokyo, Japan) · 2017Article
- Article
- IL-6 Trans-Signaling Drives Murine Crescentic GN.Journal of the American Society of Nephrology : JASN · 2016Article
- Capillary dilation and rarefaction are correlated with intracapillary inflammation in antibody-mediated rejection.Journal of immunology research · 2014Article
- Immunophenotyping in BK virus allograft nephropathy distinct from acute rejection.Clinical & developmental immunology · 2013Article
- The diagnostic value of transcription factors T-bet/GATA3 ratio in predicting antibody-mediated rejection.Clinical & developmental immunology · 2013Article
- Late and chronic antibody-mediated rejection: main barrier to long term graft survival.Clinical & developmental immunology · 2013Review
- A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.Circulation research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factors T-bet and GATA3 determine the differentiation of helper T cells into Th1 or Th2 cells, respectively. An altered ratio of their relative expression promotes the pathogenesis of certain immunological diseases, but whether this may also contribute to the pathogenesis of antibody-mediated rejection (ABMR) versus T cell-mediated rejection (TCMR) is unknown. Here, we characterized the intragraft expression of T-bet and GATA3 and determined the correlation of their levels with the presence of typical lesions of ABMR and TCMR. We found a predominant intraglomerular expression of T-bet in patients with ABMR, which was distinct from that in patients with TCMR. In ABMR, interstitial T-bet expression was typically located in peritubular capillaries, although the overall quantity of interstitial T-bet was less than that observed in TCMR. The expression of intraglomerular T-bet correlated with infiltration of CD4+ and CD8+ lymphocytes, which express T-bet, as well as intraglomerular CD68+ monocyte/macrophages, which do not express T-bet. The predominance of intraglomerular T-bet expression relative to GATA3 expression associated with poor response to treatment with bolus steroid. In summary, predominance of intraglomerular T-bet expression correlates with antibody-mediated rejection and resistance to steroid treatment.
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