ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- SYK regulates Schwann cell metabolic reprogramming to promote axonal regeneration in immune-mediated neuropathy.Journal of neuroinflammation · 2025Article
- NMDA Receptors Coordinate Metabolic Reprogramming and Mitophagy in Schwann Cells to Promote Peripheral Nerve Regeneration.Research (Washington, D.C.) · 2025Article
- Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies.Neural regeneration research · 2024Article
- TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.Cell death & disease · 2024Article
- Immune-Mediated Neuropathies: Pathophysiology and Management.International journal of molecular sciences · 2023Review
- Case Report: Plasma Biomarkers Reflect Immune Mechanisms of Guillain-Barré Syndrome.Frontiers in neurology · 2021Article
- Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (SAPP).Scientific reports · 2018Article
- Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain.Molecular neurobiology · 2017Article
- Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach.Molecular neurobiology · 2016Review
- Sialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury.Experimental neurology · 2016Article
- Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis.Neuromolecular medicine · 2015Article
- Ganglioside regulation of AMPA receptor trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration.Physiological reviews · 2014Review
- Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neutralization of schwann cell-secreted VEGF is protective to in vitro and in vivo experimental diabetic neuropathy.PloS one · 2014Article
- Changes in the GEF-H1 pathways after traumatic brain injury.Journal of neurotrauma · 2013Article
- Effect of Y-27632 on the cultured retinal neurocytes of rats.International journal of ophthalmology · 2013Article
- Article
- Autoantobodies activate small GTPase RhoA to modulate neurite outgrowth.Small GTPases · 2011Article
- Erythropoietin enhances nerve repair in anti-ganglioside antibody-mediated models of immune neuropathy.PloS one · 2011Article
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10 authors.
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Abstract
Anti-ganglioside antibodies (Abs) are strongly associated with axonal forms of Guillain Barré syndrome (GBS). Some studies indicate that these Abs, including those with GD1a reactivity, are associated with poor prognosis and/or incomplete recovery. We recently demonstrated that a disease-relevant anti-ganglioside Ab with GD1a reactivity inhibits axon regeneration after PNS injury in an animal model (Lehmann et al., 2007). An implication of these findings is that anti-GD1a Abs can mediate inhibition of axon regeneration and limit recovery in some patients with GBS. The downstream inhibitory intracellular signaling that mediates anti-ganglioside Ab-induced axon inhibition remains unclear. In the current study, we show that disease-relevant and GBS patient's anti-ganglioside Abs can inhibit neurite outgrowth in dissociated primary neuronal cultures. Activation of small GTPase RhoA and its key downstream effector Rho kinase (ROCK) are critical mediators of growth cone and neurite outgrowth inhibition. Therefore, we examined the role of these intracellular signaling molecules in our primary neuronal cultures by molecular and pharmacologic approaches. Our results show that the Ab-mediated inhibition of neurite outgrowth involves the activation of RhoA and ROCK pathway and this activation is through the engagement of specific cell-surface gangliosides by Abs. In summary, these studies directly link patient autoantibodies to an intracellular inhibitory signaling pathway involved in anti-ganglioside Ab-mediated inhibition of neurite outgrowth.
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