ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 83 citations in OpenAlex.
- Electrophysiological Profiling of Exocytosis during Early-Stage Development of the Zebrafish Lateral Line.eNeuro · 2026Article
- Activity and retinoic acid drive hair cell spatial patterning in the zebrafish utricle.Development (Cambridge, England) · 2026Article
- Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line.bioRxiv : the preprint server for biology · 2025Article
- Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells.The Journal of physiology · 2025Article
- Spontaneous calcium transients in hair cell stereocilia.Scientific reports · 2025Article
- Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells.bioRxiv : the preprint server for biology · 2024Article
- Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.Cell reports · 2023Article
- Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells.eLife · 2023Article
- Physiological responses of mechanosensory systems in the head of larval zebrafish (Frontiers in robotics and AI · 2023Article
- Probing the role of the CFrontiers in molecular neuroscience · 2023Article
- Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.Biology open · 2022Article
- Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults.eLife · 2022Article
- Article
- Tail of two fishies: age and afferents influence zebrafish lateral-line hair cell regeneration.The Journal of physiology · 2021Article
- Sensory adaptation at ribbon synapses in the zebrafish lateral line.The Journal of physiology · 2021Article
- Functional development and regeneration of hair cells in the zebrafish lateral line.The Journal of physiology · 2021Article
- Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Variability and Randomness of the Instantaneous Firing Rate.Frontiers in computational neuroscience · 2021Article
- The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea.Frontiers in cellular neuroscience · 2021Review
- Cnr2 Is Important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors.Frontiers in molecular neuroscience · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many auditory, vestibular, and lateral-line afferent neurons display spontaneous action potentials. This spontaneous spiking is thought to result from hair-cell glutamate release in the absence of stimuli. Spontaneous release at hair-cell resting potentials presumably results from Ca(V)1.3 L-type calcium channel activity. Here, using intact zebrafish larvae, we recorded robust spontaneous spiking from lateral-line afferent neurons in the absence of external stimuli. Consistent with the above assumptions, spiking was absent in mutants that lacked either Vesicular glutamate transporter 3 (Vglut3) or Ca(V)1.3. We then tested the hypothesis that spontaneous spiking resulted from sustained Ca(V)1.3 activity due to depolarizing currents that are active at rest. Mechanotransduction currents (I(MET)) provide a depolarizing influence to the resting potential. However, following block of I(MET), spontaneous spiking persisted and was characterized by longer interspike intervals and increased periods of inactivity. These results suggest that an additional depolarizing influence maintains the resting potential within the activation range of Ca(V)1.3. To test whether the hyperpolarization-activated cation current, I(h) participates in setting the resting potential, we applied I(h) antagonists. Both ZD7288 and DK-AH 269 reduced spontaneous activity. Finally, concomitant block of I(MET) and I(h) essentially abolished spontaneous activity, ostensibly by hyperpolarization outside of the activation range for Ca(V)1.3. Together, our data support a mechanism for spontaneous spiking that results from Ca(2+)-dependent neurotransmitter release at hair-cell resting potentials that are maintained within the activation range of Ca(V)1.3 channels through active I(MET) and I(h).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.