Evidence map›Paper›PMID 21289145›Full record

ArticleJournal of clinical microbiology2011

Performance of the Abbott RealTime HIV-1 viral load assay is not impacted by integrase inhibitor resistance-associated mutations.

Thomas P Young, Gavin Cloherty, Signe Fransen, Laura Napolitano, Priscilla Swanson, Christine Herman, Neil T Parkin, John Hackett

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Thomas P YoungAbbott Molecular, 1300 East Touhy Avenue, Des Plaines, IL 60018-3315, USA. tom.young@abbott.com
Gavin Cloherty
Signe Fransen
Laura Napolitano
Priscilla Swanson
Christine Herman
Neil T Parkin
John Hackett
Abbott (United States) · USAbbott Fund · USFirst Consulting Group (United States) · US

Funding

HIV/AIDS NURSING CARE AND PREVENTIONT32NR007081 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAWSON-ROSE, CAROL, VLAHOV, DAVID · 1995 to 2016
$3.8M
Novel Assays for measuring Integrase and RNase-H InhibitionR44AI057074 · NIAID · MONOGRAM BIOSCIENCES, INC. · PI PETROPOULOS, CHRISTOS J · 2006 to 2008
$2.0M
NIAID NIH HHS 5 R44 AI057074NIAID NIH HHS N01 AI050044NIAID NIH HHS R44 AI057074NINR NIH HHS T32 NR007081NINR NIH HHS T32NR007081
6 · The paper itself

Abstract

The Abbott RealTime HIV-1 viral load assay uses primers and probes targeted to integrase, which is also the target of integrase inhibitors such as raltegravir. Viral loads of 42 raltegravir-susceptible and 40 raltegravir-resistant specimens were determined using RealTime HIV-1 and Roche Monitor (v1.5). The differences in viral load measurements between assays were comparable in the two groups, demonstrating that the RealTime HIV-1 assay can tolerate raltegravir-selected mutations.

Indexed as

Mutation, MissenseAnti-HIV AgentsDrug Resistance, ViralHIV-1HIV InfectionsHIV IntegraseHumansMolecular Diagnostic TechniquesPyrrolidinonesRaltegravir PotassiumReagent Kits, DiagnosticSensitivity and SpecificityViral LoadAnti-HIV AgentsHIV Integrasep31 integrase protein, Human immunodeficiency virus 1PyrrolidinonesRaltegravir PotassiumReagent Kits, Diagnostic

Identifiers

PMID21289145
PMCPMC3122809
OpenAlexW2022899561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.