ArticleJournal of neurophysiology2011
Parasagittally aligned, mGluR1-dependent patches are evoked at long latencies by parallel fiber stimulation in the mouse cerebellar cortex in vivo.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34.Molecular neurobiology · 2021Article
- Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.Cerebellum (London, England) · 2018Review
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.Neurobiology of disease · 2018Article
- Local Estrogen Synthesis Regulates Parallel Fiber-Purkinje Cell Neurotransmission Within the Cerebellar Cortex.Endocrinology · 2018Article
- Recent advances in understanding the mechanisms of cerebellar granule cell development and function and their contribution to behavior.F1000Research · 2018Review
- Topographic Organization of Inferior Olive Projections to the Zebrin II Stripes in the Pigeon Cerebellar Uvula.Frontiers in neuroanatomy · 2018Article
- Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction.The Journal of physiology · 2017Article
- The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper.Cerebellum (London, England) · 2017Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
- Motor Learning and the Cerebellum.Cold Spring Harbor perspectives in biology · 2015Review
- Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules.Journal of neurophysiology · 2015Article
- Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits.Nature reviews. Neuroscience · 2015Review
- Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function.Frontiers in cellular neuroscience · 2015Review
- An excitatory GABA loop operating in vivo.Frontiers in cellular neuroscience · 2015Article
- Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The parallel fibers (PFs) in the cerebellar cortex extend several millimeters along a folium in the mediolateral direction. The PFs are orthogonal to and cross several parasagittal zones defined by the olivocerebellar and corticonuclear pathways and the expression of molecular markers on Purkinje cells (PCs). The functions of these two organizations remain unclear, including whether the bands respond similarly or differentially to PF input. By using flavoprotein imaging in the anesthetized mouse in vivo, this study demonstrates that high-frequency PF stimulation, which activates a beamlike response at short latency, also evokes patches of activation at long latencies. These patches consist of increased fluorescence along the beam at latencies of 20-25 s with peak activation at 35 s. The long-latency patches are completely blocked by the type 1 metabotropic glutamate receptor (mGluR(1)) antagonist LY367385. Conversely, the AMPA and NMDA glutamate receptor antagonists DNQX and APV have little effect. Organized in parasagittal bands, the long-latency patches align with zebrin II-positive PC stripes. Additional Ca(2+) imaging demonstrates that the patches reflect increases in intracellular Ca(2+). Both the PLCβ inhibitor U73122 and the ryanodine receptor inhibitor ryanodine completely block the long-latency patches, indicating that the patches are due to Ca(2+) release from intracellular stores. Robust, mGluR(1)-dependent long-term potentiation (LTP) of the patches is induced using a high-frequency PF stimulation conditioning paradigm that generates LTP of PF-PC synapses. Therefore, the parasagittal bands, as defined by the molecular compartmentalization of PCs, respond differentially to PF inputs via mGluR(1)-mediated release of internal Ca(2+).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.