ArticleMolecular biology of the cell2011
RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Retinoblastoma Protein Is Required for Epstein-Barr Virus Replication in Differentiated Epithelia.Journal of virology · 2023Article
- Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context.Cancers · 2021Article
- Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5.Journal of diabetes research · 2018Article
- Rb and p53 Liver Functions Are Essential for Xenobiotic Metabolism and Tumor Suppression.PloS one · 2016Article
- Retinoblastoma protein potentiates the innate immune response in hepatocytes: significance for hepatocellular carcinoma.Hepatology (Baltimore, Md.) · 2014Article
- The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis.Cell cycle (Georgetown, Tex.) · 2014Review
- Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.The Journal of clinical investigation · 2013Article
- Endoreplication and polyploidy: insights into development and disease.Development (Cambridge, England) · 2013Review
- Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells.Molecular biology of the cell · 2012Article
- DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression.The Journal of biological chemistry · 2012Article
- RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control.Molecular cell · 2011Article
- Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression.PloS one · 2011Article
- Targeting replication stress in glioblastoma: From genotoxic treatment and inhibitors of the DNA damage response to immunotherapy.Neuro-oncology advancesReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrity of the retinoblastoma tumor suppressor (RB) pathway is critical for restraining inappropriate proliferation and suppressing tumor development in a plethora of tissues. Here adenovirus-mediated RB deletion in the liver of adult mice led to DNA replication in the absence of productive mitotic condensation. The replication induced by RB loss was E2F-mediated and associated with the induction of DNA damage and a nontranscriptional G2/M checkpoint that targeted the accumulation of Cyclin B1. In the context of RB deletion or E2F activation, there was an increase in hepatocyte ploidy that was accompanied by hyperphysiological assembly of prereplication complexes. In keeping with this dysregulation, initiation of DNA replication was readily observed in hepatocytes that were phenotypically in G2/M. Under such conditions, uncoupling of replication initiation from mitotic progression led to altered genome ploidy in the liver. Interestingly, these findings in hepatocytes were not recapitulated in the basally proliferative tissues of the gastrointestinal tract, where RB deletion, while increasing DNA replication, did not lead to a profound uncoupling from mitosis. Combined, these findings demonstrate the critical role of RB in controlling cell-cycle transitions and underscore the importance of intrinsic tissue environments in resultant phenotypes.
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