ArticleCold Spring Harbor symposia on quantitative biology2010
Thoughts on aneuploidy.
Article in Cold Spring Harbor symposia on quantitative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Article
- The Arctic Daisy,Genes · 2026Article
- Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast.Cell genomics · 2023Article
- Identification and Genome-Wide Gene Expression Perturbation of a Trisomy in Chinese Kale (Plants (Basel, Switzerland) · 2023Article
- Genome-Wide Effects on Gene Expression Between Parental and Filial Generations of Trisomy 11 and 12 of Rice.Rice (New York, N.Y.) · 2023Article
- Phosphorylation of MAD2 at Ser195 Promotes Spindle Checkpoint Defects and Sensitizes Cancer Cells to Radiotherapy in ATM Deficient Cells.Frontiers in cell and developmental biology · 2022Article
- Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition.Life science alliance · 2020Article
- Improving Industrially Relevant Phenotypic Traits by Engineering Chromosome Copy Number inFrontiers in genetics · 2020Article
- Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics.Oncotarget · 2015Article
- Chromosomal Copy Number Variation in Saccharomyces pastorianus Is Evidence for Extensive Genome Dynamics in Industrial Lager Brewing Strains.Applied and environmental microbiology · 2015Article
- Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.PloS one · 2015Article
- Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells.Chromosoma · 2013Article
- On the origin of cancer metastasis.Critical reviews in oncogenesis · 2013Review
- New insights into the troubles of aneuploidy.Annual review of cell and developmental biology · 2012Review
- Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level. Furthermore, we find that aneuploid cells exhibit phenotypes consistent with increased energy need and proteotoxic stress. These observations, together with the finding that the additional chromosomes found in aneuploid cells are active, lead us to propose that aneuploidy causes an increased burden on protein synthesis and protein quality-control pathways and so induces an aneuploidy stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.