ArticleClinical and vaccine immunology : CVI2011
Serum IgG response to Cryptosporidium immunodominant antigen gp15 and polymorphic antigen gp40 in children with cryptosporidiosis in South India.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Trial
- Decrease in Incidence of Diarrhea Due to Cryptosporidium in Bangladeshi Children Is Associated With an Increase in Anti-Cryptosporidium Antibody Avidity.The Journal of infectious diseases · 2025Observational
- Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis.The Journal of clinical investigation · 2023Article
- An update onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides FromFrontiers in cellular and infection microbiology · 2021Article
- Cryptosporidium species and cryptosporidiosis in Japan: a literature review and insights into the role played by animals in its transmission.The Journal of veterinary medical science · 2020Review
- Effect of immunoglobulin G concentration in dairy cow colostrum and calf blood serum onVeterinary world · 2020Article
- Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Asparagine-Linked Glycans ofMolecular & cellular proteomics : MCP · 2017Article
- Article
- Serum Anti-Cryptosporidial gp15 Antibodies in Mothers and Children Less than 2 Years of Age in India.The American journal of tropical medicine and hygiene · 2015Article
- Systemic and Mucosal Immune Responses toCurrent tropical medicine reports · 2015Article
- Article
- Cryptosporidiosis in HIV/AIDS patients in Kenya: clinical features, epidemiology, molecular characterization and antibody responses.The American journal of tropical medicine and hygiene · 2014Article
- Microarray analysis of the human antibody response to synthetic Cryptosporidium glycopeptides.International journal for parasitology · 2013Article
- Cryptosporidiosis among children in an endemic semiurban community in southern India: does a protected drinking water source decrease infection?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Serum IgG responses and seroconversion patterns to Cryptosporidium gp15 among children in a birth cohort in south India.Clinical and vaccine immunology : CVI · 2012Article
- Analysis of human immune responses in quasi-experimental settings: tutorial in biostatistics.BMC medical research methodology · 2012Article
- Serum antibody responses to polymorphic Cryptosporidium mucin antigen in Bangladeshi children with cryptosporidiosis.The American journal of tropical medicine and hygiene · 2011Article
- Cryptosporidiosis in children in the Indian subcontinent.Tropical parasitologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The surface-associated glycopeptides gp40, one of the most polymorphic Cryptosporidium antigens, and gp15, one of the most immunodominant Cryptosporidium antigens, are putative vaccine candidates because they mediate infection in vitro and induce immune responses in vivo. We evaluated antibody responses to these antigens before and after the first episode of symptomatic cryptosporidiosis in 51 children from a birth cohort study in an area in South India where Cryptosporidium is endemic and a major cause of parasitic diarrhea. IgG levels to gp15 and to homotypic and heterotypic gp40 antigens were measured in pre- and postdiarrheal sera by enzyme-linked immunosorbent assay (ELISA). There was a significant IgG response to gp15 (P < 0.001) following the first episode of cryptosporidial diarrhea. Using a general additive model, we determined the estimated time of the peak IgG response to gp15 to be 9.3 weeks (confidence interval, 5.2 to 13.4) following the diarrheal episode. In a subset of 30 children infected with Cryptosporidium hominis subtype Ia, there was a significant difference in IgG responses to homotypic C. hominis Ia and to heterotypic Cryptosporidium parvum II gp40 antigens (P = 0.035). However, there was also a significant correlation (P = 0.001) in the responses to both antigens in individual children, suggesting that while responses are in part subtype specific, there is significant cross-reactivity to both antigens. This is the first report of the characterization of immune responses to cryptosporidiosis in Indian children and the first study to investigate human immune responses to the polymorphic gp40 antigen. However, further studies are needed to determine whether immune responses to these antigens are protective against subsequent infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.