ArticleBMC musculoskeletal disorders2011
Microstructure and biomechanical characteristics of bone substitutes for trauma and orthopaedic surgery.
Article in BMC musculoskeletal disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- [Augmentation techniques for the treatment of osteoporosis-associated fractures of the extremities].Unfallchirurgie (Heidelberg, Germany) · 2024Review
- Comparison of Nanocrystalline Hydroxyapatite Bone Graft with Empty Defects in Long Bone Fractures: A Retrospective Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Traumatic Fracture Treatment: Calcium Phosphate Bone Substitute Case-Control Study in Humerus, Radius, Tibia Fractures-Assessing Efficacy and Recovery Outcomes.Biomedicines · 2023Article
- Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials.Materials (Basel, Switzerland) · 2023Review
- Proximal Phalanx Enchondroma with Pathological Fracture Treated with Curettage and Bone Substitute Placement - A Case Report.Journal of orthopaedic case reports · 2022Article
- Bone Tissue Engineering in the Treatment of Bone Defects.Pharmaceuticals (Basel, Switzerland) · 2022Review
- [Cement augmentation and bone graft substitutes-Materials and biomechanics].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- Article
- Synthetic Bone Substitutes and Mechanical Devices for the Augmentation of Osteoporotic Proximal Humeral Fractures: A Systematic Review of Clinical Studies.Journal of functional biomaterials · 2020Review
- Waiting for Aπαταω: 250 Years Later.Foundations of science · 2019Article
- 3d Tissue Engineered In Vitro Models Of Cancer In Bone.ACS biomaterials science & engineering · 2018Article
- A self-organising biomimetic collagen/nano-hydroxyapatite-glycosaminoglycan scaffold for spinal fusion.Journal of materials science · 2017Article
- Clinical experience with the artificial bone graft substitute Calcibon used following curettage of benign and low-grade malignant bone tumors.Scientific reports · 2017Article
- A Comparison of Tissue Engineering Scaffolds Incorporated with Manuka Honey of Varying UMF.BioMed research international · 2017Article
- Ollier's Disease of the Iliac Bone with Sacroiliac Joint Involvement in an Adolescent Patient.Case reports in surgery · 2016Article
- Biomechanical evaluation of bone screw fixation with a novel bone cement.Biomedical engineering online · 2015Article
- Whole-scalp EEG mapping of somatosensory evoked potentials in macaque monkeys.Brain structure & function · 2015Article
- Combined Effect of a Microporous Layer and Type I Collagen Coating on a Biphasic Calcium Phosphate Scaffold for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2015Article
- Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review.BioMed research international · 2015Review
- Finger enchondroma treated with bone substituents - a case presentation.Journal of medicine and life · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany (artificial) bone substitute materials are currently available for use in orthopaedic trauma surgery. Objective data on their biological and biomechanical characteristics, which determine their clinical application, is mostly lacking. The aim of this study was to investigate structural and in vitro mechanical properties of nine bone substitute cements registered for use in orthopaedic trauma surgery in the Netherlands.
methodsSeven calcium phosphate cements (BoneSource®, Calcibon®, ChronOS®, Eurobone®, HydroSet™, Norian SRS®, and Ostim®), one calcium sulphate cement (MIIG® X3), and one bioactive glass cement (Cortoss®) were tested. Structural characteristics were measured by micro-CT scanning. Compression strength and stiffness were determined following unconfined compression tests.
resultsEach bone substitute had unique characteristics. Mean total porosity ranged from 53% (Ostim®) to 0.5% (Norian SRS®). Mean pore size exceeded 100 μm only in Eurobone® and Cortoss® (162.2 ± 107.1 μm and 148.4 ± 70.6 μm, respectively). However, 230 μm pores were found in Calcibon®, Norian SRS®, HydroSet™, and MIIG® X3. Connectivity density ranged from 27/cm3 for HydroSet™ to 0.03/cm3 for Calcibon®. The ultimate compression strength was highest in Cortoss® (47.32 MPa) and lowest in Ostim® (0.24 MPa). Young's Modulus was highest in Calcibon® (790 MPa) and lowest in Ostim® (6 MPa).
conclusionsThe bone substitutes tested display a wide range in structural properties and compression strength, indicating that they will be suitable for different clinical indications. The data outlined here will help surgeons to select the most suitable products currently available for specific clinical indications.
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