ArticleInflammatory bowel diseases2011
Sex differences in statural growth impairment in Crohn's disease: role of IGF-1.
Article in Inflammatory bowel diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Increases in IGF-1 After Anti-TNF-α Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease.The Journal of clinical endocrinology and metabolism · 2018Trial
- Association of Nutritional Status at Diagnosis with Disease Course in Pediatric Inflammatory Bowel Disease.Nutrients · 2026Article
- Bone Health in Paediatric Inflammatory Bowel Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Correlation between gut microbiota composition, enteric infections and linear growth impairment: a case-control study in childhood stunting in Pidie, Aceh, Indonesia.Gut pathogens · 2023Article
- IGF-1 and IGFBP-3 in Inflammatory Cachexia.International journal of molecular sciences · 2021Review
- Pathogenesis of Musculoskeletal Deficits in Children and Adults with Inflammatory Bowel Disease.Nutrients · 2021Review
- Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User's Guide for Adult and Pediatric Gastroenterologists.Gastroenterology · 2021Review
- Clinical Variables Associated With Statural Growth in Pediatric Crohn's Disease Differ by Sex (The Growth Study).Inflammatory bowel diseases · 2021Article
- Longitudinal growth patterns and final height in childhood-onset systemic lupus erythematosus.European journal of pediatrics · 2021Article
- Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications.Advances in nutrition (Bethesda, Md.) · 2021Review
- Introduction to and Screening Visit Results of the Multicenter Pediatric Crohn's Disease Growth Study.Inflammatory bowel diseases · 2020Article
- Growth and Puberty in Children with Inflammatory Bowel Diseases.Biomedicines · 2020Review
- Chronic inflammation and the growth hormone/insulin-like growth factor-1 axis.Central-European journal of immunology · 2020Review
- [Inflammatory bowel disease with growth hormone deficiency in adolescents: an analysis of 4 cases and literature review].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Review
- Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease.World journal of gastroenterology · 2018Observational
- Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis.Pediatric rheumatology online journal · 2018Article
- Mice with infectious colitis exhibit linear growth failure and subsequent catch-up growth related to systemic inflammation and IGF-1.Nutrition research (New York, N.Y.) · 2017Article
- Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition.Nutrition (Burbank, Los Angeles County, Calif.) · 2017Article
- Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.Frontiers in neuroendocrinology · 2015Review
- Catch-up growth occurs after diarrhea in early childhood.The Journal of nutrition · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGrowth impairment in Crohn's disease (CD) is more common in males than females for unknown reasons. Since insulin-like growth factor-1 (IGF-1) is important for statural growth, we hypothesized that IGF-1 levels are lower in males with CD.
methodsSex differences in hormone Z-scores based on chronological age (CA-Z) and bone age (BA-Z) were examined in a cross-sectional study of 82 CD patients <21 years of age (43% female).
resultsIGF-1 CA-Z and BA-Z-scores were 0.50 units (P = 0.04) and 1.24 units (P = 0.003) lower in males. Mean bone age (12.2 years) was lower than chronological age (13.1 years) (P < 0.0001). Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and albumin did not differ by sex (P ≥ 0.08), but were associated with IGF-1 CA-Z and BA-Z-scores (P ≤ 0.02). Insulin-like growth factor binding protein-3 (IGFBP-3) CA-Z and BA-Z-scores were 0.71 units (P = 0.004) and 1.26 units (P < 0.001) lower in males. Inflammatory markers were correlated with sex hormone CA-Z and BA-Z and pituitary hormone BA-Z-scores in males (P ≤ 0.03), but not females (P ≥ 0.25). IGF-1 BA-Z-scores were positively associated with height BA-Z-scores (P = 0.03). Mean height BA-Z-scores were lower in males (P = 0.03).
conclusionsLower IGF-1 levels in males may explain sex differences in growth impairment in CD. Inflammation appears to more adversely affect hormone levels and statural growth in males. Prospective longitudinal studies are needed to further clarify the role of IGF-1 in sex differences in statural growth impairment in pediatric CD.
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