Evidence map›Paper›PMID 21287564›Full record

Trial reportThe Laryngoscope2011

Variable changes in PET activity before and after rTMS treatment for tinnitus.

Mark Mennemeier, Kenneth C Chelette, Shawn Allen, Twyla B Bartel, William Triggs, Timothy Kimbrell, Joseph Crew, Tiffany Munn, Ginger J Brown, John Dornhoffer

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Laryngoscope, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02693743 (Repetitive Transcranial Magnetic Stimulation as Treatment for Acute Suicidality in Adult Patients), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02693743 naterminatednot on this mapstarted 2017, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation as Treatment for Acute Suicidality in Adult Patients

TypeinterventionalSponsorUniversity of ArkansasRan2017 to 2019Enrolled1ConditionsSuicidal IdeationArmsrepetitive transcranial magnetic stimulation (rTMS)
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Article
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  16. Review
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  19. Article
  20. Predictors for rTMS response in chronic tinnitus.Frontiers in systems neuroscience · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mark MennemeierDepartment of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. msmennemeier@uams.edu
Kenneth C Chelette
Shawn Allen
Twyla B Bartel
William Triggs
Timothy Kimbrell
Joseph Crew
Tiffany Munn
Ginger J Brown
John Dornhoffer
University of Arkansas for Medical Sciences · USUniversity of Florida · USUniversity of Tennessee Health Science Center · US

Funding

PHYSIOLOGICAL DISTURBANCES ASSOCIATED WITH NEONATAL INTRAVENTRICULAR HEMORRHAGEP20RR020146 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI HALL, WHIT · 2004 to 2011
$17.2M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029884 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI LOWERY, CURTIS L · 2009 to 2011
$11.4M
Telemedicine CoreP30GM110702 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2014 to 2018
$6.1M
Central Modulation of RhythmsR01NS020246 · NINDS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 1985 to 2012
$3.5M
Neglect and Neural Mechanisms of Magnitude EstimationR01NS039348 · NINDS · UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK · PI MENNEMEIER, MARK S · 2001 to 2004
$1.3M
Identifying and Treating Arousal-Related Deficits in Neglect and DysphagiaR21HD055677 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI MENNEMEIER, MARK S · 2009 to 2010
$363k
Rehabilitating Strength Perception After StrokeR03HD055269 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI MENNEMEIER, MARK S · 2008 to 2009
$136k
NCRR NIH HHS 1UL1RR029884NCRR NIH HHS P20 RR020146NCRR NIH HHS RR20146NCRR NIH HHS UL1 RR029884NICHD NIH HHS HD055269NICHD NIH HHS HD055677NICHD NIH HHS R03 HD055269NICHD NIH HHS R21 HD055677NIGMS NIH HHS P30 GM110702NINDS NIH HHS NS39348NINDS NIH HHS R01 NS020246NINDS NIH HHS R01 NS039348
6 · The paper itself

Abstract

objectives/hypothesisThe objective was to determine whether low-frequency repetitive transcranial magnetic stimulation (rTMS) improves tinnitus by decreasing neural activity in auditory processing regions of the temporal cortex and the utility of positron emission tomography (PET) for targeting treatment. STUDY

designRandomized, sham-controlled crossover.

methodsPatients received a five-day course of active and sham 1-Hz rTMS (1800 pulses at 110% of motor threshold) to the temporal cortex, with a week separating active and sham treatment. Visual analogue ratings of tinnitus loudness (VARL) were assessed at baseline and the end of each treatment week; regional brain blood flow (rBBF) and glucose metabolism (via PET) were measured before and after treatment in regions of interest (ROI) beneath the stimulating coil and control sites.

resultsThe VARL for both ears significantly decreased after active but not sham treatment. Responders comprised 43% of patients, experiencing at least a 33% drop in tinnitus loudness. The site most consistently associated with a positive response was the secondary auditory cortex (Brodmann Area 22) in either hemisphere. PET asymmetries were variable across patients and not always accessible to rTMS. Whereas PET activity decreased significantly beneath the stimulating coil following active treatment, similar changes occurred at control sites and after sham stimulation. Change in tinnitus perception did not correlate significantly with change in PET activity at the treatment site ROI.

conclusionsActive TMS led to a significant reduction in tinnitus loudness, but PET scans failed to support the hypothesis that low-frequency rTMS improves tinnitus by reducing cortical activation at the stimulation site, questioning the utility of PET for targeting rTMS.

Indexed as

Positron-Emission TomographyTranscranial Magnetic StimulationAdultAgedBlood GlucoseCross-Over StudiesFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPain MeasurementRegional Blood FlowTemporal LobeTinnitusBlood GlucoseFluorodeoxyglucose F18

Identifiers

PMID21287564
PMCPMC3079336
OpenAlexW2083132093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.