ArticleClinical reviews in allergy & immunology2012
Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients.
Article in Clinical reviews in allergy & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Circulating prolactin levels and the effect of dopaminergic agonists in systemic lupus erythematosus: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The effects of bromocriptine on preventing postpartum flare in systemic lupus erythematosus patients from South China.Journal of immunology research · 2015Trial
- Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology.International journal of molecular sciences · 2024Review
- Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases.Nutrients · 2023Review
- Prolactin Increases the Frequency of Follicular T Helper Cells with Enhanced IL21 Secretion and OX40 Expression in Lupus-Prone MRL/lpr Mice.Journal of immunology research · 2021Article
- Hyperprolactinaemia.Journal of clinical medicine · 2019Review
- Autoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort.Journal of endocrinological investigation · 2019Article
- Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?Clinical rheumatology · 2019Review
- Article
- Association of extrapituitary prolactin promoter polymorphism with disease susceptibility and anti-RNP antibodies in Mexican patients with systemic lupus erythematosus.Archives of medical science : AMS · 2018Article
- Prolactin and Autoimmunity.Frontiers in immunology · 2018Review
- Morbidity and mortality in patients with hyperprolactinaemia: the PROLEARS study.Endocrine connections · 2017Article
- Article
- Prolactin has a pathogenic role in systemic lupus erythematosus.Immunologic research · 2017Article
- Prevalence of autoimmune disease in patients with prolactinomas and non-functioning pituitary adenomas.Pituitary · 2016Article
- Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?Advanced biomedical research · 2016Article
- Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity.BMC endocrine disorders · 2015Article
- Prolactin variations during risperidone therapy in a sample of drug-naive children and adolescents.International clinical psychopharmacology · 2015Observational
- No male predominance in offspring of women with rheumatoid arthritis or systemic lupus erythematosus.Immunologic research · 2014Article
- The challenge of treating orphan disease.Clinical reviews in allergy & immunology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort. Age- and sex-adjusted prolactin concentration was assessed in 256 serum samples from lupus patients utilizing the LIASON prolactin automated immunoassay method (DiaSorin S.p.A, Saluggia, Italy). Disease activity was defined as present if European Consensus Lupus Activity Measurement (ECLAM) > 2 or Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) > 4. Lupus manifestations were grouped by organ involvement, laboratory data, and prescribed medications. Hyperprolactinemia was presented in 46/256 (18%) of the cohort. Hyperprolactinemic patients had significantly more serositis (40% vs. 32.4%, p = 0.03) specifically, pleuritis (33% vs. 17%, p = 0.02), pericarditis (30% vs. 12%, p = 0.002), and peritonitis (15% vs. 0.8%, p = 0.003). Hyperprolactinemic subjects exhibited significantly more anemia (42% vs. 26%, p = 0.02) and marginally more proteinuria (65.5% vs. 46%, p = 0.06). Elevated levels of prolactin were not significantly associated with other clinical manifestations, serology, or therapy. Disease activity scores were not associated with hyperprolactinemia. Hyperprolactinemia in lupus patients is associated with all types of serositis and anemia but not with other clinical, serological therapeutic measures or with disease activity. These results suggest that dopamine agonists may be an optional therapy for lupus patients with hyperprolactinemia.
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