ArticlePediatric surgery international2011
Gender differences in reduced substance P (SP) in children with slow-transit constipation.
Article in Pediatric surgery international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- The Analysis of miRNA-mRNA Network Regulation Revealed the Mechanism of Different Drugs-Induced Constipation in Mice.Biochemical genetics · 2026Article
- Effects of Three Microbiome-Based Therapies on Loperamide-Induced Constipation in Mice by Restoring Intestinal Motility and Modulating the Intestinal Microbiota.Probiotics and antimicrobial proteins · 2026Article
- Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Soluble Dietary Fiber of Hawthorn Relieves Constipation Induced by Loperamide Hydrochloride by Improving Intestinal Flora and Inflammation, Thereby Regulating the Aquaporin Ion Pathway in Mice.Foods (Basel, Switzerland) · 2024Article
- Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota.Pharmaceutical biology · 2023Article
- Gastrointestinal Fermentable Polysaccharide Is Beneficial in Alleviating Loperamide-Induced Constipation in Mice.Nutrients · 2023Article
- Laxative effect of Wenyang Yiqi Decoction on loperamide-induced astriction model mice.Annals of translational medicine · 2023Article
- Laxative Effects of Yangyin Tongmi Capsule on a Model of Diphenoxylate-Induced Constipation in Mice.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Article
- Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation.International journal of molecular medicine · 2018Article
- Gender disparity in pediatrics: a review of the current literature.Italian journal of pediatrics · 2018Review
- The association between substance P and white matter integrity in medication-naive patients with major depressive disorder.Scientific reports · 2017Article
- Transabdominal electrical stimulation (TES) for the treatment of slow-transit constipation (STC).Pediatric surgery international · 2015Review
- Predictors of slow colonic transit in children.Pediatric surgery international · 2015Article
- Therapeutic effect of activated carbon-induced constipation mice with Lactobacillus fermentum Suo on treatment.International journal of molecular sciences · 2014Article
- Development and developmental disorders of the enteric nervous system.Nature reviews. Gastroenterology & hepatology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdult slow-transit constipation (STC) occurs predominantly in females and is associated with low numbers of substance P (SP)-containing nerves in colonic circular muscle.
aimTo determine if reduced SP nerves is female predominant in paediatric STC.
methodsChildren with STC were identified from records of more than 600 nuclear transit studies (NTS) and intestinal biopsies done for intractable chronic constipation between November 1998 and March 2009. Colonic seromuscular biopsies collected from hepatic and splenic flexures, and sigmoid colon were processed for immunohistochemistry. Nerve fibre density in circular muscle containing SP was measured qualitatively by a pathologist.
resultsEighty-eight children with chronic constipation had both NTS and intestinal biopsies. Seventy-eight children (52 M; age 2-15.5 years; mean 7.7 years) had STC diagnosed by NTS. SP was reduced in 10/26 girls, but only 11/52 boys.
conclusionIn this sample, STC was more common in boys than girls. However, in girls with STC, SP deficiency occurred in 40%, when compared with 20% of boys. During puberty, the percentage of girls with reduced SP decreased, whilst the percentage of boys increased. These results suggest that STC is heterogeneous and that there are some gender differences, the implication of which requires further investigation.
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