ArticleClinical reviews in allergy & immunology2012
Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of Vitamin D with the immune system.
Article in Clinical reviews in allergy & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- The role of alemtuzumab in the development of secondary autoimmunity in multiple Sclerosis: a systematic review.Journal of neuroinflammation · 2024Pooled it
- Vitamins andFrontiers in nutrition · 2021Pooled it
- Vitamin D inflammatory cytokines and coronary events: a comprehensive review.Clinical reviews in allergy & immunology · 2013Trial
- Importance of vitamin D in gastrointestinal health and disease.Frontiers in nutrition · 2026Review
- H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study.BMC infectious diseases · 2024Article
- Creating a Framework for Treating Autoimmune Gastritis-The Case for Replacing Lost Acid.Nutrients · 2024Review
- Association of serum vitamin D levels on Helicobacter pylori infection: a retrospective study with real-world data.BMC gastroenterology · 2023Article
- Vitamin D and Its Association withNutrients · 2023Review
- 25-hydroxyvitamin D levels in children of different ages and with varying degrees ofFrontiers in pediatrics · 2023Article
- The Crosstalk between Vitamin D and Pediatric Digestive Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency.Nutrients · 2022Review
- Factors Affect the Eradication Rate ofInfection and drug resistance · 2022Article
- Pharmacological insights into autophagy modulation in autoimmune diseases.Acta pharmaceutica Sinica. B · 2021Review
- Article
- The Association between Serum Vitamin D Levels andNutrients · 2021Article
- Common Pitfalls in the Management of Patients with Micronutrient Deficiency: Keep in Mind the Stomach.Nutrients · 2021Review
- Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.The Journal of experimental medicine · 2021Article
- Autoimmune gastritis.Nature reviews. Disease primers · 2020Review
- A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues.International journal of molecular sciences · 2019Review
- Influence of serum vitamin D level on Helicobacter pylori eradication: A multi-center, observational, prospective and cohort study.Journal of digestive diseases · 2019Observational
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1,25-Dihydroxyvitamin D displays immunoregulatory and anti-inflammatory properties, and the cells involved in innate and adaptive immune response express the vitamin D receptor and can both produce and respond to this hormone. This article aims at describing the complex immune regulatory role of vitamin D and depicting whether a correlation exists between atrophic type A gastritis and hypovitaminosis. We studied 62 autoimmune gastritis (AIG) patients and compared them to 54 lymphocytic gastritis patients, 21 Helicobacter pylori gastritis patients and 212 healthy subjects. We also statistically analyzed vitamin D concentration in 36,384 outpatients referred to our clinical laboratories. 25-Hydroxyvitamin D levels, the measurable metabolite used to determine vitamin D status in plasma, were measured by a chemiluminescent method. Average level of 25-OHD in AIG subjects was 9.8 ± 5.6 ng/mL (95% confidence interval (CI) 8.4-11.2), 11.1 ± 8.4 (CI 7.5-14.7) in H. pylori gastritis patients, 22.2 ± 13.5 (CI 18.6-25.8) in nonspecific lymphocytic gastritis patients, 21.3 ± 12.2 (CI 19.7-22.9) in healthy subjects, and 21.8 ± 13.1 (CI 21.7-21.9) in the 36,384 outpatients. Vitamin D levels in AIG patients were significantly lower than in patients with nonspecific gastritis or in the general population, supporting the hypothesis that hypovitaminosis D might be a risk factor for the development of autoimmune diseases. The low vitamin D concentration in H. pylori gastritis patients might act as predisposing factor for a more severe Th1-type aggression to the stomach epithelium.
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