ArticleExperimental brain research2011
Complementary gain modifications of the cervico-ocular (COR) and angular vestibulo-ocular (aVOR) reflexes after canal plugging.
Article in Experimental brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- The influence of cervical movement on eye stabilization reflexes: a randomized trial.Experimental brain research · 2018Trial
- Current and future advances in practice: cervical spondylosis and mechanical neck pain.Rheumatology advances in practice · 2025Review
- [Semicircular canal occlusion].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Review
- Video Ocular Counter-Roll (vOCR): Otolith-Ocular Function and Compensatory Effect of the Neck Following Vestibular Loss.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2023Article
- The Role of Neck Input in Producing Corrective Saccades in the Head Impulse Test.Frontiers in neurology · 2022Article
- Occlusion of two semicircular canals does not disrupt normal hearing in adult mice.Frontiers in neurology · 2022Article
- Cervical Injury Assessments for Concussion Evaluation: A Review.Journal of athletic training · 2016Review
- Dynamic visual acuity testing for screening patients with vestibular impairments.Journal of vestibular research : equilibrium & orientation · 2012Article
- Plasticity during Vestibular Compensation: The Role of Saccades.Frontiers in neurology · 2012Article
- Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section.Experimental brain research · 2011Article
- Compensation following bilateral vestibular damage.Frontiers in neurology · 2011Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
To determine whether the COR compensates for the loss of aVOR gain, independent of species, we studied cynomolgus and rhesus monkeys in which all six semicircular canals were plugged. Gains and phases of the aVOR and COR were determined at frequencies ranging from 0.02 to 6 Hz and fit with model-based transfer functions. Following canal plugging in a rhesus monkey, the acute stage aVOR gain was small and there were absent responses to thrusts of yaw rotation. In the chronic state, aVOR behavior was characterized by a cupula/endolymph time constant of ≈ 0.07 s, responding only to high frequencies of head rotation. COR gains were ≈ 0 before surgery but increased to ≈ 0.15 at low frequencies just after surgery; the COR gains increased to ≈ 0.4 over the next 12 weeks. Nine weeks after surgery, the summated aVOR + COR responses compensated for head velocity in space in the 0.5-3 Hz frequency range. The gains and phases continued to improve until the 35th week, where the combined aVOR + COR stabilized with gains of ≈ 0.5-0.6 and the phases were compensatory over all frequencies. Two cynomolgus monkeys operated 3-12 years earlier had similar frequency characteristics of the aVOR and COR. The combined aVOR + COR gains were ≈ 0.4-0.8 with compensatory phases. To achieve gains close to 1.0, other mechanisms may contribute to gaze compensation, especially with the head free. Thus, while there are individual variations in the time of adaptation of the gain and phase parameters, the essential functional organization of the adaption to vestibular lesions is uniform across these species.
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