ArticleHepatology international2010
Epidemiologic risk factors of hepatocellular carcinoma in a rural region of Egypt.
Article in Hepatology international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies.Nutrition journal · 2023Pooled it
- Pooled it
- Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption with Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Cancer risk in waterpipe smokers: a meta-analysis.International journal of public health · 2017Pooled it
- Nut consumption and risk of cancer and type 2 diabetes: a systematic review and meta-analysis.Nutrition reviews · 2015Pooled it
- Associations between pesticide exposure and hepatobiliary disease among agricultural workers in the Northeastern region of Thailand: a cross-sectional study.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Wide Sexual Dimorphism of Hepatocellular Carcinoma Presentation in Algeria.Gastrointestinal tumors · 2019Article
- Pesticide exposure and liver cancer: a review.Cancer causes & control : CCC · 2017Review
- Non‑infective occupational risk factors for hepatocellular carcinoma: A review (Review).Molecular medicine reports · 2017Review
- Pesticide exposure and hepatocellular carcinoma risk: A case-control study using a geographic information system (GIS) to link SEER-Medicare and California pesticide data.Environmental research · 2015Article
- New insights on non-B non-C hepatocellular carcinoma in mid Delta Region, Egypt.Journal of gastrointestinal cancer · 2014Article
- Knowledge and perceptions of hepatitis C infection and pesticides use in two rural villages in Egypt.BMC public health · 2014Article
- Serum anti-P53 antibodies and alpha-fetoprotein in patients with non-B non-C hepatocellular carcinoma.SpringerPlus · 2013Article
- Geographic distribution of hematopoietic cancers in the Nile delta of Egypt.Annals of oncology : official journal of the European Society for Medical Oncology · 2012Article
- Risk of hepatocellular carcinoma in workers exposed to chemicals.Hepatitis monthly · 2012Article
- Hepatitis C virus and other risk factors in hepatocellular carcinoma.Acta virologica · 2012Article
- Clinical profile, BRCA2 expression, and the androgen receptor CAG repeat region in Egyptian and Moroccan male breast cancer patients.Breast disease · 2011Article
- Research training of students in minority and international settings: lessons learned from cancer epidemiology education in special populations.Journal of cancer education : the official journal of the American Association for Cancer Education · 2010Article
- Relevance of serum levels of interleukin-6 and syndecan-1 in patients with hepatocellular carcinoma.Scientia pharmaceuticaArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatocellular carcinoma (HCC) is a major health problem worldwide, including Egypt. In the recent past, HCC has become the second most prevalent cancer among men in Egypt. Since HCC has not been well studied in the rural population of Egypt, this case-control study was conducted to investigate the epidemiologic risk factors of HCC in the predominantly rural region of Gharbiah, Egypt.
methodsA total of 150 cases and 150 controls matched to cases on age (±5 years) and sex were recruited from the Gharbiah Cancer Society and Tanta Cancer Center. Exposure data were collected by an interviewer-administered standardized questionnaire about epidemiologic, occupational, medical and family history of HCC. Conditional logistic regression was utilized to calculate unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI). The effect modification of HCC risk between viral infection and environmental risk factors was also assessed.
resultsBeing an industrial worker was an independent risk for developing HCC (OR 3.54, 95% CI 1.18, 10.63) after adjusting for viral infection, schistosomiasis and tobacco smoking. High relative risk of HCC was observed among HCV-infected individuals who were farmers (OR 9.60, 95% CI 3.72, 24.76), industrial workers (OR 12.90, 95% CI 4.33, 38.43) or active smokers (OR 5.95, 95% CI 2.20, 16.08).
conclusionOccupational exposure may play an important role in the development of HCC. Farming, industrial exposures and cigarette smoking may increase the risk of HCC among HCV-seropositive individuals. Future research focusing on mechanisms of occupational exposures among HCV patients in this population is needed.
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