ArticleSleep2011
Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila.
Article in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 108 citations in OpenAlex.
- Sleep deprivation induces anxiety-like behaviors through IL-6 driven astrocyte-GABAergic neuron crosstalk in the PAG-ACC circuit.Journal of neuroinflammation · 2026Article
- Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Mechanistic study on electroacupuncture-regulated circadian autophagy for inhibiting ferroptosis in hippocampal neurons and alleviating depression-like behaviors in adulthood induced by early chronic sleep deprivation.Frontiers in neurology · 2025Article
- Article
- Longitudinal relationships between lifestyle risk factors and neurodevelopment in early adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.Integrative and comparative biology · 2023Review
- Article
- Sleep deprivation, sleep fragmentation, and social jet lag increase temperature preference inFrontiers in neuroscience · 2023Article
- Sleep benefits different stages of memory inFrontiers in physiology · 2023Review
- A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila.PLoS biology · 2022Article
- Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila.Current biology : CB · 2022Article
- Neural consequences of chronic sleep disruption.Trends in neurosciences · 2022Review
- Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact host landing and blood feeding.The Journal of experimental biology · 2022Article
- Article
- Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior.PLoS biology · 2021Article
- Neonicotinoids disrupt memory, circadian behaviour and sleep.Scientific reports · 2021Article
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
- The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila.Journal of visualized experiments : JoVE · 2020Article
- Natural selection on sleep duration in Drosophila melanogaster.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesMultiple lines of evidence indicate that sleep is important for the developing brain, although little is known about which cellular and molecular pathways are affected. Thus, the aim of this study was to determine whether the early adult life of Drosophila, which is associated with high amounts of sleep and critical periods of brain plasticity, could be used as a model to identify developmental processes that require sleep. SUBJECTS: Wild type Canton-S Drosophila melanogaster. DESIGN;
interventionFlies were sleep deprived on their first full day of adult life and allowed to recover undisturbed for at least 3 days. The animals were then tested for short-term memory and response-inhibition using aversive phototaxis suppression (APS). Components of dopamine signaling were further evaluated using mRNA profiling, immunohistochemistry, and pharmacological treatments. MEASUREMENTS AND
resultsFlies exposed to acute sleep deprivation on their first day of life showed impairments in short-term memory and response inhibition that persisted for at least 6 days. These impairments in adult performance were reversed by dopamine agonists, suggesting that the deficits were a consequence of reduced dopamine signaling. However, sleep deprivation did not impact dopaminergic neurons as measured by their number or by the levels of dopamine, pale (tyrosine hydroxylase), dopadecarboxylase, and the Dopamine transporter. However, dopamine pathways were impacted as measured by increased transcript levels of the dopamine receptors D2R and dDA1. Importantly, blocking signaling through the dDA1 receptor in animals that were sleep deprived during their critical developmental window prevented subsequent adult learning impairments.
conclusionsThese data indicate that sleep plays an important and phylogenetically conserved role in the developing brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.