ArticleSleep2011
Relationship of sleep quantity and quality with 24-hour urinary catecholamines and salivary awakening cortisol in healthy middle-aged adults.
Article in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis.Journal of global health · 2018Pooled it
- Adrenal fatigue does not exist: a systematic review.BMC endocrine disorders · 2016Pooled it
- Association between sleep duration and cardiac structure in youths at risk for metabolic syndrome.Scientific reports · 2016Trial
- Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes.European journal of applied physiology · 2014Trial
- CPAP therapy prevents increase in blood pressure after upper airway surgery for obstructive sleep apnoea.Sleep & breathing = Schlaf & Atmung · 2013Trial
- Insomnia and the Risk of Atrial Fibrillation: A Nationwide, Real-World Cohort Study.Journal of the American Heart Association · 2026Article
- Mediating role of metabolic factors in the association between dietary habits and the onset of type 2 diabetes: a population-based Panasonic cohort study 19.BMJ nutrition, prevention & health · 2026Article
- Sleep habits in the pathogenesis and management of diabesity.Journal of diabetes investigation · 2025Review
- The Correlation Between Sleep and Coronary Heart Disease: A Review.Reviews in cardiovascular medicine · 2025Review
- Impact of Circadian Rhythm and Sleep Architecture Changes on Prognosis in Patients with Acute Hemorrhagic Stroke.Nature and science of sleep · 2025Article
- Disease Modules Associated with Unfavorable Sleep Patterns and Their Genetic Determinants: A Prospective Cohort Study of the UK Biobank.Phenomics (Cham, Switzerland) · 2024Article
- Sleep Duration and Blood Pressure in Youth Referred for Elevated Blood Pressure Evaluation.Pediatrics · 2024Article
- Lifestyle factors associated with presenteeism among city government office workers: a cross-sectional study.Journal of occupational health · 2024Article
- The impact of sleep problems on cerebral aneurysm risk is mediated by hypertension: a mediated Mendelian randomization study.Frontiers in genetics · 2024Article
- Association between Sleep Quality and Cardiac Autonomic Modulation in Adolescents: A Cross Sectional Study.Sleep science (Sao Paulo, Brazil) · 2023Article
- Objective Sleep Duration and All-Cause Mortality Among People With Obstructive Sleep Apnea.JAMA network open · 2023Article
- Nonrestorative sleep is a risk factor for metabolic syndrome in the general Japanese population.Diabetology & metabolic syndrome · 2023Article
- Associations between Various Sleep-Wake-Related Indicators and Nutritional Status in Community-Dwelling Older Adults: The Yilan Study, Taiwan.The journal of nutrition, health & aging · 2023Article
- Sleep characteristics before assisted reproductive technology treatment predict reproductive outcomes: a prospective cohort study of Chinese infertile women.Frontiers in endocrinology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesa. Explore the stability in sleep/wake patterns of middle-aged adults over a 3-year follow-up period. b. Explore the relationship between objectively measured sleep indices, urinary catecholamines, and salivary cortisol.
designNaturalistic follow-up for sleep/wake patterns (n = 114) by 2-week sleep log and cross-sectional design for objective sleep assessments and hormonal measures (n = 96) at follow-up period nearly 3 years after baseline measurements.
settingCommunity
participantsHealthy middle-aged adults
interventionsN/A. MEASUREMENTS AND
resultsThere were high correlations between baseline and follow-up period (2.6 ± 0.5 years) on sleep/wake patterns (r = 0.6-0.79) as measured by 2-week sleep log. For wave 2 cross-sectional study, objective poor sleepers (3-day actigraphy sleep efficiency < 85%) had a higher 24-h urinary norepinephrine (NE) level (205.7 ± 105 nmol/d vs 162.1 ± 55.6 nmol/d, P = 0.03) and a nearly significantly higher 24-h urinary epinephrine (E) level (P = 0.12) than good sleepers. There were no differences in 3-day mean salivary awakening cortisol and 24-h urinary catecholamines (NE and E) between short and normal/long sleepers. Linear regression results, however, showed that shorter time in bed and actual sleep time, longer sleep onset latency, and lower sleep efficiency were correlated with higher 24-h urinary E and NE (all P < 0.05) but not salivary cortisol. The effect of poor sleep quality on 24-h urinary catecholamines was stronger in males than females.
conclusionsIncreased sympathetic activity as measured by 24-h urinary catecholamines might play a critical role in the pathogenesis mediating the relationship of insufficient sleep (quantity and quality) with subsequent cardiovascular and metabolic complications. Salivary awakening cortisol was not associated with sleep quantity and quality in healthy middle-aged adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.