ReviewDeutsches Arzteblatt international2011
The diagnosis and treatment of soft tissue sarcomas of the limbs.
Review in Deutsches Arzteblatt international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Clinicopathological and prognostic significance of PD-L1 expression in sarcoma: A systematic review and meta-analysis.Medicine · 2018Pooled it
- [Open biopsy of bone and soft tissue tumors : guidelines for precise surgical procedures].Operative Orthopadie und Traumatologie · 2012Guideline
- [Significance of sonographically guided percutaneous needle biopsy in the diagnostics of soft tissue tumors].Der Orthopade · 2013Trial
- The effect of intraoperative radiotherapy in musculoskeletal malignancy: A population study from US SEER database.Journal of Cancer · 2025Article
- Article
- Diagnostic Superiority of Dual-Time Point [Diagnostics (Basel, Switzerland) · 2023Article
- The diagnostic accuracy of 332 incisional biopsies in patients with malignant tumors in the musculoskeletal system.World journal of surgical oncology · 2023Article
- Microsurgical Reconstruction in Orthopedic Tumor Resections as Part of a Multidisciplinary Surgical Approach for Sarcomas of the Extremities.Life (Basel, Switzerland) · 2022Review
- Clinical Routine and Necessary Advances in Soft Tissue Tumor Imaging Based on the ESSR Guideline: Initial Findings.Tomography (Ann Arbor, Mich.) · 2022Article
- Accuracy of core needle biopsy for histologic diagnosis of soft tissue sarcoma.Scientific reports · 2022Article
- Ewing Sarcoma Misdiagnosed as a Traumatic Hematoma: A Case from Family Practice.The American journal of case reports · 2021Article
- Efficacy and Cost-Benefit Analysis of Magnetic Resonance Imaging in the Follow-Up of Soft Tissue Sarcomas of the Extremities and Trunk.Journal of oncology · 2021Article
- [Biopsy of musculoskeletal tumors : Complications and avoidable errors].Der Orthopade · 2020Review
- Correlation of p16 and nm23-H1 expression levels with incidence and prognosis of soft tissue sarcoma.Oncology letters · 2019Article
- PD-L1 Expression Is Associated with FOXP3+ Regulatory T-Cell Infiltration of Soft Tissue Sarcoma and Poor Patient Prognosis.Journal of Cancer · 2017Article
- Managing Soft Tissue Sarcomas in a Developing Health System.World journal of surgery · 2016Article
- Soft Tissue Sarcomas of the Arm - Oncosurgical and Reconstructive Principles within a Multimodal, Interdisciplinary Setting.Frontiers in surgery · 2016Review
- Article
- Is revisional surgery mandatory when an unexpected sarcoma diagnosis is made following primary surgery?World journal of surgical oncology · 2015Article
- Identification of a blood-borne miRNA signature of synovial sarcoma.Molecular cancer · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of soft-tissue sarcomas of the limbs is often delayed, sometimes markedly so, even though prompt and appropriate treatment improves survival and lowers the amputation rate.
methodsOn the basis of a selective literature review and consideration of the relevant guidelines, we developed an algorithm that can serve as a guide to the diagnosis of soft-tissue tumors in general and to the treatment of soft-tissue sarcomas of the limbs.
resultsSurgical resection accompanied by multimodal therapy is the only treatment strategy for soft-tissue sarcoma that provides a chance of cure. Particularly when the tumor is located in the distal part of a limb, plastic-reconstructive surgical techniques often enable adequate local control, along with limb salvage and preservation of function. The role of adjuvant or neo-adjuvant radiotherapy and/or chemotherapy is currently debated. The overall survival rate at 5 years is 87% for low-grade sarcomas and 62% for high-grade sarcomas.
conclusionAny solid mass of the limbs that has been present for more than four weeks requires diagnostic evaluation. Excisional biopsy is suitable only for epifascial lesions measuring less than 5 cm in diameter. All other lesions should be imaged with MRI and then diagnosed with an incisional biopsy. Patients with soft tissue sarcomas must be treated in an interdisciplinary collaboration so that they can undergo multimodal treatment. The proposed algorithm should help avoid delays in diagnosis and optimize treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.