SynthesisDeutsches Arzteblatt international2011
Oocyte donation: a risk factor for pregnancy-induced hypertension: a meta-analysis and case series.
Synthesis in Deutsches Arzteblatt international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02174328 (Prevention of Preeclampsia With Aspirin Administered From the Beginning of Pregnancy in Recipients of Donated Oocytes.), which is not on this map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Preeclampsia With Aspirin Administered From the Beginning of Pregnancy in Recipients of Donated Oocytes.
Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- The risk for the development of hypertensive complications in oocyte donation pregnancy: a systematic review and individual participant data meta-analysis (DONOR IPD).Human reproduction update · 2026Pooled it
- Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses.BMC pregnancy and childbirth · 2021Pooled it
- Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2019Pooled it
- Risk of hypertensive disorders in pregnancy following assisted reproductive technology: overview and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2017Pooled it
- Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review.Reproductive biology and endocrinology : RB&E · 2016Pooled it
- Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2016Pooled it
- Obstetric and maternal outcomes of IVF and oocyte donation pregnancies among women ages 40-45-a large cohort study.Journal of assisted reproduction and genetics · 2024Article
- Balancing risks and rewards in the context of shared motherhood IVF.Human reproduction (Oxford, England) · 2023Article
- Maternal and neonatal outcomes of pregnancies with COVID-19 after medically assisted reproduction: results from the prospective COVID-19-Related Obstetrical and Neonatal Outcome Study.American journal of obstetrics and gynecology · 2022Observational
- Article
- Diseases and complications of the puerperium.Deutsches Arzteblatt international · 2021Review
- Hypertensive Disorders in Pregnant Women Receiving Fertility Treatments.International journal of fertility & sterility · 2018Article
- Pregnancy Achieved Using Donor Eggs in Cancer Survivors with Treatment-Induced Ovarian Failure: Obstetric and Perinatal Outcome.Journal of women's health (2002) · 2018Article
- Correlation of hypertensive disorders in pregnancy with procedures ofExperimental and therapeutic medicine · 2017Article
- A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health.Seminars in immunopathology · 2016Review
- Neonatal outcomes in pregnancies resulting from oocyte donation: a cohort study in Sweden.BMC pediatrics · 2016Observational
- Adverse obstetric outcomes in pregnancies resulting from oocyte donation: a retrospective cohort case study in Sweden.BMC pregnancy and childbirth · 2015Article
- Diagnosis and Treatment of Hypertensive Pregnancy Disorders. Guideline of DGGG (S1-Level, AWMF Registry No. 015/018, December 2013).Geburtshilfe und Frauenheilkunde · 2015Article
- Relationship between maternal immunological response during pregnancy and onset of preeclampsia.Journal of immunology research · 2014Review
- Patterns of globalized reproduction: Egg cells regulation in Israel and Austria.Israel journal of health policy research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 2008 and 2009, the authors saw in their institution three women who had undergone oocyte donation and went on to develop severe de novo hypertension before the 26(th) week of gestation, with values above 180/110 mm Hg. Pregnancy was prematurely terminated in these cases because of the acute threat to the mother's life, and none of the three neonates survived. Five further cases with better outcomes were found to have occurred from 2006 to 2010. On the basis of this experience, the authors performed a meta-analysis to determine whether oocyte donation elevates the risk of pregnancy-induced hypertension (PIH). The cases are discussed in detail.
methodsSystematic review of the literature on PIH after oocyte donation, with meta-analysis and calculation of an odds ratio. We also provide a retrospective chart review of our own case series.
results28 publications were evaluated. The overall rate of PIH in a total of 2308 deliveries after oocyte donation was 22.6%. With the aid of data from 11 studies, the course of pregnancy in a total of 644 oocyte recipients was compared to that in a control group of 2320 women who were not oocyte recipients. The calculated odds ratio for PIH after oocyte donation, compared to conventional reproductive therapy, was 2.57 (95% CI, 1.91-3.47), while the calculated odds ratio for PIH after oocyte donation, compared to other women in the control group, was 6.60 (95% CI, 4.55-9.57).
conclusionThe data reveal that oocyte donation confers a considerable risk that the recipient will develop PIH. The very early and severe cases of preeclampsia that we report here are rather atypical; similar cases may have occurred elsewhere without finding their way into the relevant literature. The authors recommend close surveillance of pregnancies following allogenic oocyte transplantation by physicians with special expertise in prenatal medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.