ArticleMolecular biology and evolution2011
Neutral evolution of robustness in Drosophila microRNA precursors.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- miR-137 targets Myc to regulate growth during eye development.Development (Cambridge, England) · 2025Article
- Evolution and Phylogeny of MicroRNAs - Protocols, Pitfalls, and Problems.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Genetic robustness of let-7 miRNA sequence-structure pairs.RNA (New York, N.Y.) · 2019Article
- Towards a Consistent, Quantitative Evaluation of MicroRNA Evolution.Journal of integrative bioinformatics · 2017Article
- The Expansion of Animal MicroRNA Families Revisited.Life (Basel, Switzerland) · 2015Article
- MicroRNAs influence reproductive responses by females to male sex peptide in Drosophila melanogaster.Genetics · 2014Article
- On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.Annual review of ecology, evolution, and systematics · 2014Article
- The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution.RNA (New York, N.Y.) · 2013Article
- Heterogeneous ensemble approach with discriminative features and modified-SMOTEbagging for pre-miRNA classification.Nucleic acids research · 2013Article
- Article
- MicroRNA precursors are not structurally robust but plastic.Genome biology and evolution · 2013Article
- The underlying molecular and network level mechanisms in the evolution of robustness in gene regulatory networks.PLoS computational biology · 2013Article
- Evolutionary relationships between miRNA genes and their activity.BMC genomics · 2012Article
- Evolutionary conservation of histone modifications in mammals.Molecular biology and evolution · 2012Article
- Describing the structural robustness landscape of bacterial small RNAs.BMC evolutionary biology · 2012Article
- Article
- Evolutionary conserved microRNAs are ubiquitously expressed compared to tick-specific miRNAs in the cattle tick Rhipicephalus (Boophilus) microplus.BMC genomics · 2011Article
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Authors and funding
5 authors.
Funding
Abstract
Mutational robustness describes the extent to which a phenotype remains unchanged in the face of mutations. Theory predicts that the strength of direct selection for mutational robustness is at most the magnitude of the rate of deleterious mutation. As far as nucleic acid sequences are concerned, only long sequences in organisms with high deleterious mutation rates and large population sizes are expected to evolve mutational robustness. Surprisingly, recent studies have concluded that molecules that meet none of these conditions--the microRNA precursors (pre-miRNAs) of multicellular eukaryotes--show signs of selection for mutational and/or environmental robustness. To resolve the apparent disagreement between theory and these studies, we have reconstructed the evolutionary history of Drosophila pre-miRNAs and compared the robustness of each sequence to that of its reconstructed ancestor. In addition, we "replayed the tape" of pre-miRNA evolution via simulation under different evolutionary assumptions and compared these alternative histories with the actual one. We found that Drosophila pre-miRNAs have evolved under strong purifying selection against changes in secondary structure. Contrary to earlier claims, there is no evidence that these RNAs have been shaped by either direct or congruent selection for any kind of robustness. Instead, the high robustness of Drosophila pre-miRNAs appears to be mostly intrinsic and likely a consequence of selection for functional structures.
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