SynthesisAmerican journal of obstetrics and gynecology2011
Nifedipine in the management of preterm labor: a systematic review and metaanalysis.
Synthesis in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 8 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Comparative efficacy of transdermal nitroglycerin and oral nifedipine in managing preterm labor: a systematic review and meta-analysis of randomized controlled trials.BMC pediatrics · 2025Pooled it
- Pooled it
- Comparison of the efficacy of nifedipine with ritodrine, nitroglycerine and magnesium sulfate for the management of preterm labor: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Ethanol for preventing preterm birth in threatened preterm labor.The Cochrane database of systematic reviews · 2015Pooled it
- Transdermal nitroglycerin for the treatment of preterm labor: a systematic review and metaanalysis.American journal of obstetrics and gynecology · 2013Pooled it
- Relaxin for preventing preterm birth.The Cochrane database of systematic reviews · 2013Pooled it
- The prevention, diagnosis and treatment of premature labor.Deutsches Arzteblatt international · 2013Pooled it
- Vaginal progesterone vs. cervical cerclage for the prevention of preterm birth in women with a sonographic short cervix, previous preterm birth, and singleton gestation: a systematic review and indirect comparison metaanalysis.American journal of obstetrics and gynecology · 2013Pooled it
- Misoprostol administered sublingually at a dose of 12.5 μg versus vaginally at a dose of 25 μg for the induction of full-term labor: a randomized controlled trial.Reproductive health · 2020Trial
- Does nifedipine improve outcomes of embryo transfer?: Interim analysis of a randomized, double blinded, placebo-controlled trial.Medicine · 2019Trial
- A double-blinded, randomized, placebo-controlled trial assessing the effects of nifedipine on embryo transfer: Study protocol.Medicine · 2017Trial
- Nifedipine-associated maternal oxygen desaturation in an IVF twin pregnancy complicated by preterm premature rupture of membranes: a case report.AJOG global reports · 2026Article
- Pre-pregnancy evaluation of essential hypertensive women with poor obstetric history.Revista da Associacao Medica Brasileira (1992) · 2026Article
- PIEZO channels link mechanical forces to uterine contractions in parturition.Science (New York, N.Y.) · 2025Article
- The genetic architecture of cervical length is shared with spontaneous preterm birth risk.Communications medicine · 2025Article
- Review
- Cervical sliding sign and cervical funneling in the third trimester as predictors of spontaneous preterm birth in singleton pregnancy.Quantitative imaging in medicine and surgery · 2025Article
- Psychomotor development, emotional regulation, and executive functions in 2-years-old children after threatened preterm labour: a prospective cohort study.European child & adolescent psychiatry · 2025Article
- Evaluation of Diagnostic Recommendations Embedded in Medication Alerts: Prospective Single-Arm Interventional Study.Journal of medical Internet research · 2025Article
- Delayed-Interval Delivery in Multifetal In Vitro Fertilization (IVF) Pregnancies: Two Case Reports.Cureus · 2025Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine the efficacy and safety of nifedipine as a tocolytic agent in women with preterm labor. STUDY
designA systematic review and metaanalysis of randomized controlled trials.
resultsTwenty-six trials (2179 women) were included. Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gestation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, neonatal jaundice, and admission to the neonatal intensive care unit when compared with β₂-adrenergic-receptor agonists. There was no difference between nifedipine and magnesium sulfate in tocolytic efficacy. Nifedipine was associated with significantly fewer maternal adverse events than β₂-adrenergic-receptor agonists and magnesium sulfate. Maintenance nifedipine tocolysis was ineffective in prolonging gestation or improving neonatal outcomes when compared with placebo or no treatment.
conclusionNifedipine is superior to β₂-adrenergic-receptor agonists and magnesium sulfate for tocolysis in women with preterm labor.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.