ArticlePsychological medicine2011
Haemoglobin A1c, fasting glucose and future risk of elevated depressive symptoms over 2 years of follow-up in the English Longitudinal Study of Ageing.
Article in Psychological medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The bidirectional longitudinal association between depressive symptoms and HbADiabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder.World journal of psychiatry · 2026Article
- Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults.BMC medicine · 2025Article
- Temporal Relationship between HbA1c and Depressive Symptom Trajectories in a Longitudinal Cohort Study: The Mediating Role of Healthy Lifestyles.Brain sciences · 2024Article
- Metabolic Profile and Long-Term Risk of Depression, Anxiety, and Stress-Related Disorders.JAMA network open · 2024Article
- Article
- Depressive Symptoms Longitudinally Mediate the Effect of Hyperglycemia on Memory Decline in Type 2 Diabetes.Diabetes care · 2023Observational
- Increased Levels of HbA1c in Individuals with Type 2 Diabetes and Depression: A Meta-Analysis of 34 Studies with 68,398 Participants.Biomedicines · 2022Review
- Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.Journal of women's health (2002) · 2021Article
- The relationship between diabetes and depressive symptoms in men with or at risk of HIV infection.HIV medicine · 2021Article
- Subjective wellbeing as a determinant of glycated hemoglobin in older adults: longitudinal findings from the English Longitudinal Study of Ageing.Psychological medicine · 2020Article
- Diabetes increases the risk of depression: A systematic review, meta-analysis and estimates of population attributable fractions based on prospective studies.Preventive medicine reports · 2019Review
- Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.Aging and disease · 2019Article
- Prospective Study of Glycated Hemoglobin and Trajectories of Depressive Symptoms: The China Health and Retirement Longitudinal Study.Aging and disease · 2019Article
- Risk of Depression and Suicidality among Diabetic Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2018Review
- Fasting Glucose and the Risk of Depressive Symptoms: Instrumental-Variable Regression in the Cardiovascular Risk in Young Finns Study.International journal of behavioral medicine · 2017Article
- Hemoglobin ADiabetes care · 2017Observational
- Quantitative assessment of the bidirectional relationships between diabetes and depression.Oncotarget · 2017Article
- Article
- Diabetes mellitus and disturbances in brain connectivity: a bidirectional relationship?Neuromolecular medicine · 2014Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe cross-sectional association between impaired glucose/diabetes and depression is inconsistent. We examined the longitudinal associations between diabetes, indicators of glucose metabolism and depressive symptoms over 2 years of follow-up.
methodParticipants were 4338 men and women from the English Longitudinal Study of Ageing, a prospective study of community-dwelling older adults [aged 62.9 (s.d.=9.0) years, 45.2% men]. Depressive symptoms were assessed at baseline and after 2 years of follow-up using the eight-item Centre of Epidemiological Studies--Depression (CES-D) scale. Glycated haemoglobin (HbA1c) levels, fasting glucose and other biological and behavioural risk factors were also assessed at baseline.
resultsApproximately 11.5% of the sample were categorized with elevated depressive symptoms at follow-up (a score ≥ 4 on the CES-D). There was an association between HbA1c and depressive symptoms at follow-up [per unit increase, odds ratio (OR) 1.17, 95% confidence interval (CI) 1.03-1.33] after adjustment for age and baseline CES-D. Cross-sectionally, the probability of depressive symptoms increased with increasing HbA1c levels until the value of 8.0% after which there was a plateau [p(curve)=0.03]. Compared with those with normal fasting glucose, participants with diabetes (confirmed through self-report or elevated fasting blood glucose) at baseline had an elevated risk of depressive symptoms at follow-up (OR 1.52, 95% CI 1.01-2.30) after adjusting for depressive symptoms at baseline, behavioural and sociodemographic variables, adiposity and inflammation.
conclusionsThese data suggest that poor glucose metabolism and diabetes are risk factors for future depression in older adults. There was no evidence of a U-shaped association.
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