ArticleBMC genomics2011
Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Metabolic engineering of Parageobacillus thermoglucosidasius for thermophilic production of 1-butanol.AMB Express · 2025Article
- Alleviation of Carbon Catabolite Repression throughApplied and environmental microbiology · 2023Article
- Production of butanol from lignocellulosic biomass: recent advances, challenges, and prospects.RSC advances · 2022Review
- Sporulation in solventogenic and acetogenic clostridia.Applied microbiology and biotechnology · 2021Review
- Response characteristics of the membrane integrity and physiological activities of the mutant strain Y217 under exogenous butanol stress.Applied microbiology and biotechnology · 2021Article
- Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis.Applied microbiology and biotechnology · 2021Article
- RRNPP-type quorum sensing affects solvent formation and sporulation inMicrobiology (Reading, England) · 2020Article
- Consolidated bioprocessing for butanol production of cellulolytic Clostridia: development and optimization.Microbial biotechnology · 2020Review
- Pathway dissection, regulation, engineering and application: lessons learned from biobutanol production by solventogenic clostridia.Biotechnology for biofuels · 2020Review
- Article
- Simplifying multidimensional fermentation dataset analysis and visualization: One step closer to capturing high-quality mutant strains.Scientific reports · 2017Article
- Metabolite labelling reveals hierarchies in Clostridium acetobutylicum that selectively channel carbons from sugar mixtures towards biofuel precursors.Microbial biotechnology · 2017Article
- Integrated intracellular metabolic profiling and pathway analysis approaches reveal complex metabolic regulation by Clostridium acetobutylicum.Microbial cell factories · 2016Article
- Sugar uptake by the solventogenic clostridia.World journal of microbiology & biotechnology · 2016Article
- Transcriptional analysis of micronutrient zinc-associated response for enhanced carbohydrate utilization and earlier solventogenesis in Clostridium acetobutylicum.Scientific reports · 2015Article
- Hierarchy in pentose sugar metabolism in Clostridium acetobutylicum.Applied and environmental microbiology · 2015Article
- Simultaneous fermentation of glucose and xylose to butanol by Clostridium sp. strain BOH3.Applied and environmental microbiology · 2014Article
- Enhanced whole genome sequence and annotation of Clostridium stercorarium DSM8532T using RNA-seq transcriptomics and high-throughput proteomics.BMC genomics · 2014Article
- Recognition of Protein-coding Genes Based on Z-curve Algorithms.Current genomics · 2014Article
- Genetic resources for advanced biofuel production described with the Gene Ontology.Frontiers in microbiology · 2014Review
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Authors and funding
10 authors.
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Abstract
backgroundClostridium acetobutylicum, a gram-positive and spore-forming anaerobe, is a major strain for the fermentative production of acetone, butanol and ethanol. But a previously isolated hyper-butanol producing strain C. acetobutylicum EA 2018 does not produce spores and has greater capability of solvent production, especially for butanol, than the type strain C. acetobutylicum ATCC 824.
resultsComplete genome of C. acetobutylicum EA 2018 was sequenced using Roche 454 pyrosequencing. Genomic comparison with ATCC 824 identified many variations which may contribute to the hyper-butanol producing characteristics in the EA 2018 strain, including a total of 46 deletion sites and 26 insertion sites. In addition, transcriptomic profiling of gene expression in EA 2018 relative to that of ATCC824 revealed expression-level changes of several key genes related to solvent formation. For example, spo0A and adhEII have higher expression level, and most of the acid formation related genes have lower expression level in EA 2018. Interestingly, the results also showed that the variation in CEA_G2622 (CAC2613 in ATCC 824), a putative transcriptional regulator involved in xylose utilization, might accelerate utilization of substrate xylose.
conclusionsComparative analysis of C. acetobutylicum hyper-butanol producing strain EA 2018 and type strain ATCC 824 at both genomic and transcriptomic levels, for the first time, provides molecular-level understanding of non-sporulation, higher solvent production and enhanced xylose utilization in the mutant EA 2018. The information could be valuable for further genetic modification of C. acetobutylicum for more effective butanol production.
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