ArticleNeural development2011
Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic.
Article in Neural development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- KAT6A is essential for developmental control gene expression in neural stem and progenitor cells.PLoS genetics · 2026Article
- Insulinoma-associated 1 promotes neurogenic proliferation of cortical basal progenitors but is largely dispensable for projection neuron production.bioRxiv : the preprint server for biology · 2026Article
- Regulatory interplay of cyclin D1 and INSM1 in suppressing INSL6 expression: Implications for breast cancer biology.Biochemistry and biophysics reports · 2025Article
- Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis.Stem cell reports · 2025Article
- Review
- Review
- Review
- Article
- Transcriptome Analysis Reveals Olfactory System Expression Characteristics of Aquatic Snakes.Frontiers in genetics · 2022Article
- Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?Human pathology · 2020Review
- Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.Nature · 2018Article
- Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development.Molecular neurobiology · 2018Review
- INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma.Journal of neuropathology and experimental neurology · 2018Article
- INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes.Translational lung cancer research · 2018Article
- Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.Developmental biology · 2017Article
- Article
- Expression of the insulinoma-associated 1 (insm1) gene in Xenopus laevis tadpole retina and brain.Gene expression patterns : GEP · 2016Article
- Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization.BMC medical genomics · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInsm1 is a zinc-finger transcription factor transiently expressed throughout the developing nervous system in late progenitors and nascent neurons. Insm1 is also highly expressed in medulloblastomas and other neuroendocrine tumors.
resultsWe generated mice lacking the Insm1 gene and used them to elucidate its role in neurogenic proliferation of the embryonic olfactory epithelium. We found that deletion of Insm1 results in more apical cells and fewer nascent and mature neurons. In the embryonic olfactory epithelium of Insm1 mutants we detect fewer basal progenitors, which produce neurons, and more apical progenitors, which at this stage produce additional progenitors. Furthermore, in the mutants we detect fewer progenitors expressing NEUROD1, a marker of terminally dividing, neuronogenic (neuron-producing) progenitors (immediate neuronal precursors), and more progenitors expressing ASCL1, a marker of the transit amplifying progenitors that migrate from the apical to the basal edges of the epithelium while dividing to generate the terminal, neuronogenic progenitors. Finally, with timed administration of nucleoside analogs we demonstrate that the Insm1 mutants contain fewer terminally dividing progenitors at embryonic day 12.5.
conclusionsAltogether, these results suggest a role for Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic. This role appears partially conserved with that of its nematode ortholog, egl-46. The similar effects of Insm1 deletion on progenitors of embryonic olfactory epithelium and cortex point to striking parallels in the development of these neuroepithelia, and particularly between the basal progenitors of olfactory epithelium and the subventricular zone progenitors of cortex.
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