ArticleNeural development2011
NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrain.
Article in Neural development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- The NKCC1 Antagonist Bumetanide, Administered After Prenatal Alcohol Exposure, Mitigates Ethanol-Induced Aberrance in Tangential Migration of GABAergic Interneurons in Mouse Medial Prefrontal Cortex.Alcohol, clinical & experimental research · 2026Article
- Altered ClProceedings of the National Academy of Sciences of the United States of America · 2021Article
- NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data.Cells · 2020Review
- Nerves in the Tumor Microenvironment: Origin and Effects.Frontiers in cell and developmental biology · 2020Review
- Overlapping migratory mechanisms between neural progenitor cells and brain tumor stem cells.Cellular and molecular life sciences : CMLS · 2019Review
- Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1.Journal of neuroinflammation · 2018Article
- In vivo migration of endogenous brain progenitor cells guided by an injectable peptide amphiphile biomaterial.Journal of tissue engineering and regenerative medicine · 2018Article
- Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration.Communicative & integrative biology · 2018Article
- Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells During Development.Stem cells (Dayton, Ohio) · 2017Article
- NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression.Pflugers Archiv : European journal of physiology · 2015Article
- Review
- PACAP modulation of calcium ion activity in developing granule cells of the neonatal mouse olfactory bulb.Journal of neurophysiology · 2015Article
- Ion transporters in brain tumors.Current medicinal chemistry · 2015Review
- Regulation of adult neurogenesis by GABAergic transmission: signaling beyond GABAA-receptors.Frontiers in cellular neuroscience · 2014Review
- GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity.Frontiers in cellular neuroscience · 2014Article
- Direct control of Na(+)-K(+)-2Cl(-)-cotransport protein (NKCC1) expression with aldosterone.American journal of physiology. Cell physiology · 2014Article
- Functional circuits of new neurons in the dentate gyrus.Frontiers in neural circuits · 2013Review
- Neural stem cells: mechanisms and modeling.Protein & cell · 2012Review
- Identification of key residues involved in the dimerization of the secretory Na(+)-K(+)-2Cl(-) cotransporter NKCC1.Biochemistry · 2011Article
- Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration.American journal of physiology. Cell physiology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From an early postnatal period and throughout life there is a continuous production of olfactory bulb (OB) interneurons originating from neuronal precursors in the subventricular zone. To reach the OB circuits, immature neuroblasts migrate along the rostral migratory stream (RMS). In the present study, we employed cultured postnatal mouse forebrain slices and used lentiviral vectors to label neuronal precursors with GFP and to manipulate the expression levels of the Na-K-2Cl cotransporter NKCC1. We investigated the role of this Cl- transporter in different stages of postnatal neurogenesis, including neuroblast migration and integration in the OB networks once they have reached the granule cell layer (GCL). We report that NKCC1 activity is necessary for maintaining normal migratory speed. Both pharmacological and genetic manipulations revealed that NKCC1 maintains high [Cl-]i and regulates the resting membrane potential of migratory neuroblasts whilst its functional expression is strongly reduced at the time cells reach the GCL. As in other developing systems, NKCC1 shapes GABAA-dependent signaling in the RMS neuroblasts. Also, we show that NKCC1 controls the migration of neuroblasts in the RMS. The present study indeed indicates that the latter effect results from a novel action of NKCC1 on the resting membrane potential, which is independent of GABAA-dependent signaling. All in all, our findings show that early stages of the postnatal recruitment of OB interneurons rely on precise, orchestrated mechanisms that depend on multiple actions of NKCC1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.