Evidence map›Paper›PMID 21284836›Full record

ArticleGenome biology2011

MM-ChIP enables integrative analysis of cross-platform and between-laboratory ChIP-chip or ChIP-seq data.

Yiwen Chen, Clifford A Meyer, Tao Liu, Wei Li, Jun S Liu, Xiaole Shirley Liu

Abstract read
In one paragraph

Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Leveraging biological replicates to improve analysis in ChIP-seq experiments.Computational and structural biotechnology journal · 2014
    Article
  4. Article
  5. Unifying model for molecular determinants of the preselection Vβ repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  6. Article
  7. Differential principal component analysis of ChIP-seq.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  8. Computational methodology for ChIP-seq analysis.Quantitative biology (Beijing, China) · 2013
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiwen ChenDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, 44 Binney Street, Boston, MA 02115, USA.
Clifford A Meyer
Tao Liu
Wei Li
Jun S Liu
Xiaole Shirley Liu

Funding

ProteomicsU19DK062434 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI LAZAR, MITCHELL A. · 2002 to 2011
$37.4M
Computational Models for Mechanisms of Global Transcription RegulationR01HG004069 · NHGRI · DANA-FARBER CANCER INST · PI LIU, XIAOLE SHIRLEY · 2006 to 2013
$3.6M
NHGRI NIH HHS HG004069NIDDK NIH HHS DK62434
6 · The paper itself

Abstract

The ChIP-chip and ChIP-seq techniques enable genome-wide mapping of in vivo protein-DNA interactions and chromatin states. The cross-platform and between-laboratory variation poses a challenge to the comparison and integration of results from different ChIP experiments. We describe a novel method, MM-ChIP, which integrates information from cross-platform and between-laboratory ChIP-chip or ChIP-seq datasets. It improves both the sensitivity and the specificity of detecting ChIP-enriched regions, and is a useful meta-analysis tool for driving discoveries from multiple data sources.

Indexed as

Genome, HumanAlgorithmsChromatinChromatin ImmunoprecipitationChromosome MappingDNA-Binding ProteinsGenomicsHumansOligonucleotide Array Sequence AnalysisSensitivity and SpecificitySoftwareChromatinDNA-Binding Proteins

Identifiers

PMID21284836
PMCPMC3188793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.