ArticleCardiovascular diabetology2011
Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery disease.
Article in Cardiovascular diabetology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.Cardiovascular diabetology · 2011Trial
- Association of oxidative stress, inflammation, and ADIPOQ gene expression in young adults at risk of non-alcoholic fatty liver disease and cardiovascular disease.The Pan African medical journal · 2026Article
- Adiponectin and Adiponectin Receptors in Atherosclerosis.Endocrine reviews · 2025Review
- Circulating adiponectin levels, expression of adiponectin receptors, and methylation of adiponectin gene promoter in relation to Alzheimer's disease.BMC medical genomics · 2022Article
- Review
- Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy.Chinese medicine · 2021Article
- Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells.Frontiers in immunology · 2021Article
- Adiponectin Inhibits the Production of TNF-α, IL-6 and Chemokines by Human Lung Macrophages.Frontiers in pharmacology · 2021Article
- Role of Adiponectin Gene and Receptor Polymorphisms and Their mRNA Levels with Serum Adiponectin Level in Myocardial Infarction.The application of clinical genetics · 2020Article
- Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations.Journal of atherosclerosis and thrombosis · 2019Observational
- Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North-African Tunisian population.Journal of clinical laboratory analysis · 2018Article
- Integrated Immunomodulatory Mechanisms through which Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate Obese Adipose Tissue Dysfunction.Nutrients · 2017Review
- Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children.PloS one · 2017Observational
- Association of two Common Single Nucleotide Polymorphisms (+45T/G and +276G/T) of ADIPOQ Gene with Coronary Artery Disease in Type 2 Diabetic Patients.Iranian biomedical journal · 2016Article
- Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men.Biology of sport · 2015Article
- Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Fish Oil-Derived Long-Chain n-3 Polyunsaturated Fatty Acids Reduce Expression of M1-Associated Macrophage Markers in an ex vivo Adipose Tissue Culture Model, in Part through Adiponectin.Frontiers in nutrition · 2015Article
- Expression of Adiponectin Receptors on Peripheral Blood Leukocytes of Hypertensive Children Is Associated with the Severity of Hypertension.BioMed research international · 2015Article
- Adiponectin as a potential biomarker of vascular disease.Vascular health and risk management · 2015Review
- Association between risk factors for vascular dementia and adiponectin.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdiponectin has insulin-sensitizing and anti-atherosclerotic effects, partly mediated through its action on monocytes. We aimed to determine adiponectin levels and expression of its receptors (AdipoR1 and AdipoR2) in peripheral monocytes from overweight and obese patients with coronary artery disease (CAD).
methodsFifty-five overweight/obese patients, suspected for CAD, underwent coronary angiography: 31 were classified as CAD patients (stenosis ≥ 50% in at least one main vessel) and 24 as nonCAD. Quantitative RT-PCR and flow cytometry were used for determining mRNA and protein surface expression of adiponectin receptors in peripheral monocytes. A high sensitivity multiplex assay (xMAP technology) was used for the determination of plasma adiponectin and interleukin-10 (IL-10) secreted levels.
resultsPlasma adiponectin levels were decreased in CAD compared to nonCAD patients (10.9 ± 3.1 vs. 13.8 ± 5.8 μg/ml respectively, p = 0.033). In multivariable analysis, Matsuda index was the sole independent determinant of adiponectin levels. AdipoR1 and AdipoR2 protein levels were decreased in monocytes from CAD compared to nonCAD patients (59.5 ± 24.9 vs. 80 ± 46 and 70.7 ± 39 vs. 95.6 ± 47.8 Mean Fluorescence Intensity Arbitrary Units respectively, p < 0.05). No significant differences were observed concerning the mRNA levels of the adiponectin receptors between CAD and nonCAD patients. AdipoR2 protein levels were positively correlated with plasma adiponectin and Matsuda index (r = 0.36 and 0.31 respectively, p < 0.05 for both). Furthermore, basal as well as adiponectin-induced IL-10 release was reduced in monocyte-derived macrophages from CAD compared to nonCAD subjects.
conclusionsOverweight patients with CAD compared to those without CAD, had decreased plasma adiponectin levels, as well as decreased surface expression of adiponectin receptors in peripheral monocytes. This fact together with the reduced adiponectin-induced IL-10 secretion from CAD macrophages could explain to a certain extent, an impaired atheroprotective action of adiponectin.
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