ReviewBritish journal of clinical pharmacology2011
Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment.
Review in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 3 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Are Mind-Body Exercise Beneficial for Treating Pain, Function, and Quality of Life in Middle-Aged and Old People With Chronic Pain? A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Identifying and Managing Pain in People with Alzheimer's Disease and Other Types of Dementia: A Systematic Review.CNS drugs · 2016Pooled it
- Opioids for agitation in dementia.The Cochrane database of systematic reviews · 2015Pooled it
- Population Pharmacokinetic/Pharmacodynamic Modeling of O-Desmethyltramadol in Young and Elderly Healthy Volunteers.Drugs & aging · 2019Trial
- Tolerability of buprenorphine transdermal system in nursing home patients with advanced dementia: a randomized, placebo-controlled trial (DEP.PAIN.DEM).Clinical interventions in aging · 2018Trial
- Risk of hospitalization and opioid use in older people with dementia.BMC geriatrics · 2026Article
- Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap.Journal of pain research · 2026Review
- Development of a set of indicators for the quality of chronic pain management in Chinese community-dwelling older adults: a Delphi study.BMC geriatrics · 2024Article
- Article
- Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.Redox report : communications in free radical research · 2024Review
- Opioids in geriatric units in 14 Belgian hospitals: prevalence, dosage and associated factors.Annals of medicine · 2024Article
- The effects of chronic neuropathic pain states on the discriminative stimulus effect of fentanyl and other MOR agonists.bioRxiv : the preprint server for biology · 2024Article
- Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults.Drugs & aging · 2024Review
- Inflammation in Older Poles with Localized and Widespread Chronic Pain-Results from a Population-Based PolSenior Study.Journal of clinical medicine · 2024Article
- Emergency Awake Laparotomy Using Neuraxial Anaesthesia: A Case Series and Literature Review.Journal of personalized medicine · 2024Article
- Observational evidence linking psychotropic medicines to the dispensing of opioid agents in later life.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024Observational
- Opioid use and subsequent delirium risk in patients with advanced cancer in palliative care: a multicenter registry study.Scientific reports · 2024Article
- Perspectives on approaching pain management in patients with dementia.Pain management · 2024Review
- Patients with dementia: prevalence and type of drug-drug interactions.Frontiers in pharmacology · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is highly prevalent in frail older people who often have multiple co-morbidities and multiple medicines. Rational prescribing of analgesics in frail older people is complex due to heterogeneity in drug disposition, comorbid medical conditions, polypharmacy and variability in analgesic response in this population. A critical issue in managing older people with pain is the need for judicious choice of analgesics based on a comprehensive medical and medication history. Care is needed in the selection of analgesic medicine to avoid drug-drug or drug-disease interactions. People living with dementia and cognitive impairment have suboptimal pain relief which in part may be related to altered pharmacodynamics of analgesics and challenges in the systematic assessment of pain intensity in this patient group. In the absence of rigorously controlled trials in frail older people and those with cognitive impairment a pharmacologically-guided approach can be used to optimize pain management which requires a systematic understanding of the pharmacokinetics and pharmacodynamics of analgesics in frail older people with or without changes in cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.