ReviewBritish journal of clinical pharmacology2011
Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers.
Review in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Sensitivity of cognitive function tests to acute hypoxia in healthy subjects: a systematic literature review.Frontiers in physiology · 2023Pooled it
- First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulator.Clinical and translational science · 2023Trial
- Change in brain asymmetry reflects level of acute alcohol intoxication and impacts on inhibitory control.Scientific reports · 2023Trial
- Episodic foresight is impaired following acute alcohol intoxication.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Trial
- Moderate acute alcohol intoxication increases visual motion repulsion.Scientific reports · 2018Trial
- Pharmacodynamic interactions of a solid formulation of sodium oxybate and ethanol in healthy volunteers.British journal of clinical pharmacology · 2015Trial
- Pharmacokinetics and central nervous system effects of the novel dual NK1 /NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers.British journal of clinical pharmacology · 2013Trial
- Problematic Alcohol Use Among Adolescents in Germany: Representative Cross-Sectional Study.JMIR public health and surveillance · 2026Article
- Promising strategies for the prevention of alcohol-related brain damage through optimised management of acute alcohol withdrawal: A focussed literature review.Journal of psychopharmacology (Oxford, England) · 2025Review
- Insula under the influence: Alcohol-induced changes in resting state functional connectivity.Alcohol, clinical & experimental research · 2025Article
- The prevalence of alcohol-related deaths in autopsies performed in Lithuania between 2017 and 2020: a cross-sectional study.European journal of public health · 2024Article
- Parental drinking and observations of parent-child problem-solving discussions: Do drinking motives matter?Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023Article
- Assessing driving-relevant attentional impairment after a multiday drinking session: A two-phase pilot study.Alcoholism, clinical and experimental research · 2022Article
- What does current science tell us about the accuracy, reliability, and completeness of intoxicated witnesses? A case example of the murder of a prime minister.Frontiers in psychology · 2022Article
- Alcohol and the Risk of Injury.Nutrients · 2021Review
- Dose-dependent sensorimotor impairment in human ocular tracking after acute low-dose alcohol administration.The Journal of physiology · 2021Article
- Article
- Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety.Acta pharmacologica Sinica · 2019Review
- A Review of Developmental Considerations in Human Laboratory Alcohol Research.Current addiction reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central nervous system (CNS) effects of acute alcohol administration have been frequently assessed. Such studies often use a wide range of methods to study each of these effects. Unfortunately, the sensitivity of these tests has not completely been ascertained. A literature search was performed to recognize the most useful tests (or biomarkers) for identifying the acute CNS effects of alcohol in healthy volunteers. All tests were grouped in clusters and functional domains. Afterwards, the effect of alcohol administration on these tests was scored as improvement, impairment or as no effect. Furthermore, dose-response relationships were established. A total number of 218 studies, describing 342 different tests (or test variants) were evaluated. Alcohol affected a wide range of CNS domains. Divided attention, focused attention, visuo-motor control and scales of feeling high and of subjective drug effects were identified as the most sensitive functional biomarkers for the acute CNS effects of alcohol. The large number of CNS tests that are used to determine the effects of alcohol interferes with the identification of the most sensitive ones and of drug-response relationships. Our results may be helpful in selecting rational biomarkers for studies investigating the acute CNS effects of alcohol or for future alcohol- interaction studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.