Evidence map›Paper›PMID 21284673›Full record

ReviewAlcoholism, clinical and experimental research2011

Alcoholic liver disease and malnutrition.

Craig J McClain, Shirish S Barve, Ashutosh Barve, Luis Marsano

Open access · bronzeAbstract readReview
In one paragraph

Review in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. The association between alcohol consumption and pulmonary function: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Observational
  17. Alcohol-related hepatitis: A review article.World journal of gastroenterology · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Craig J McClainDepartment of Medicine, University of Louisville School of Medicine, Kentucky 40292, USA. cjmccl01@gwise.louisville.edu
Shirish S Barve
Ashutosh Barve
Luis Marsano
University of Louisville · US

Funding

Strategic Vision & Impact on Environmental HealthP30ES014443 · NIEHS · UNIVERSITY OF LOUISVILLE · PI RAMOS, KENNETH S. · 2007 to 2010
$4.4M
Tumor Necrosis Factor and Alcoholic Liver DiseaseR37AA010762 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2001 to 2010
$3.6M
S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver DiseaseR01AA015970 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2005 to 2010
$2.0M
The Role of Alcohol in HIV Therapy HepatotoxicityR01AA018016 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S, EATON, JOHN W · 2008 to 2012
$1.7M
Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseR01AA018869 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2009 to 2013
$1.7M
Biomarkers for SteatohepatitisRC2AA019385 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2009 to 2010
$1.6M
Mechanisms of Alcohol-Induced ImmunosuppressionR01AA014371 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S · 2004 to 2010
$1.6M
Mechanisms of S-adenosylmethionine in NASHR01DK071765 · NIDDK · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2005 to 2009
$1.5M
Alcohol Liver Disease and Alcohol-Nutrient InteractionsP01AA017103 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2008 to 2010
$1.3M
University of Louisville Bioinformatics Faculty Recruitment for EpigeneticsP30AA019360 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2009 to 2010
$811k
Alcohol, Proteasome Dysfunction in Liver InjuryI01BX000350 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI MCCLAIN, CRAIG J. · 2009 to 2013
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BLRD VA I01 BX000350NIAAA NIH HHS P01 AA017103NIAAA NIH HHS P01AA017103NIAAA NIH HHS P30 AA019360NIAAA NIH HHS P30AA019360NIAAA NIH HHS R01 AA014371NIAAA NIH HHS R01AA014371NIAAA NIH HHS R01 AA015970NIAAA NIH HHS R01AA015970NIAAA NIH HHS R01 AA018016NIAAA NIH HHS R01AA018016NIAAA NIH HHS R01 AA018869NIAAA NIH HHS R01AA018869NIAAA NIH HHS R37 AA010762NIAAA NIH HHS R37AA010762NIAAA NIH HHS RC2 AA019385NIAAA NIH HHS RC2AA019385NIDDK NIH HHS R01 DK071765NIDDK NIH HHS R01DK071765NIEHS NIH HHS P30 ES014443NIEHS NIH HHS P30ES014443
6 · The paper itself

Abstract

Malnutrition, both protein energy malnutrition (PEM) and deficiencies in individual nutrients, is a frequent complication of alcoholic liver disease (ALD). Severity of malnutrition correlates with severity of ALD. Malnutrition also occurs in patients with cirrhosis due to etiologies other than alcohol. The mechanisms for malnutrition are multifactorial, and malnutrition frequently worsens in the hospital due to fasting for procedures and metabolic complications of liver disease, such as hepatic encephalopathy. Aggressive nutritional support is indicated in inpatients with ALD, and patients often need to be fed through an enteral feeding tube to achieve protein and calorie goals. Enteral nutritional support clearly improves nutrition status and may improve clinical outcome. Moreover, late-night snacks in outpatient cirrhotics improve nutritional status and lean body mass. Thus, with no FDA-approved therapy for ALD, careful nutritional intervention should be considered as frontline therapy.

Indexed as

AnimalsEnergy IntakeHumansLiver Diseases, AlcoholicMalnutritionNutritional StatusNutritional Support

Identifiers

PMID21284673
PMCPMC3771636
OpenAlexW1505596598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.