ArticlePLoS biology2011
The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Foxn3 is required to suppress aberrant ciliogenesis in nonphotoreceptor retinal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cilia and transcription: a mini review.Frontiers in cell and developmental biology · 2025Review
- A nonneural miRNA cluster mediates hearing via repression of two neural targets.Genes & development · 2023Article
- A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi.Genetics · 2023Article
- The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia inFrontiers in molecular neuroscience · 2023Article
- AFrontiers in cell and developmental biology · 2022Article
- Article
- Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.Nucleic acids research · 2020Article
- Survey of the Ciliary Motility Machinery ofFrontiers in genetics · 2019Article
- The regulation of cilium assembly and disassembly in development and disease.Development (Cambridge, England) · 2018Review
- Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity.Nature cell biology · 2018Article
- Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.The Journal of cell biology · 2018Article
- An RNAi Screen Identifies New Genes Required for Normal Morphogenesis of Larval Chordotonal Organs.G3 (Bethesda, Md.) · 2018Article
- All in the family: proneural bHLH genes and neuronal diversity.Development (Cambridge, England) · 2018Review
- Characterization of the human RFX transcription factor family by regulatory and target gene analysis.BMC genomics · 2018Article
- Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation.PLoS genetics · 2018Article
- Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- RFX transcription factors are essential for hearing in mice.Nature communications · 2015Article
- Article
- HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.PLoS genetics · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. Whilst the role of proneural factors in fate specification is well studied, the link between neural specification and the cellular pathways that ultimately must be activated to construct specialised neurons is usually obscure. High-resolution temporal profiling of gene expression reveals the events downstream of atonal proneural gene function during the development of Drosophila chordotonal (mechanosensory) neurons. Among other findings, this reveals the onset of expression of genes required for construction of the ciliary dendrite, a key specialisation of mechanosensory neurons. We determine that atonal activates this cellular differentiation pathway in several ways. Firstly, atonal directly regulates Rfx, a well-known highly conserved ciliogenesis transcriptional regulator. Unexpectedly, differences in Rfx regulation by proneural factors may underlie variations in ciliary dendrite specialisation in different sensory neuronal lineages. In contrast, fd3F encodes a novel forkhead family transcription factor that is exclusively expressed in differentiating chordotonal neurons. fd3F regulates genes required for specialized aspects of chordotonal dendrite physiology. In addition to these intermediate transcriptional regulators, we show that atonal directly regulates a novel gene, dilatory, that is directly associated with ciliogenesis during neuronal differentiation. Our analysis demonstrates how early cell fate specification factors can regulate structural and physiological differentiation of neuronal cell types. It also suggests a model for how subtype differentiation in different neuronal lineages may be regulated by different proneural factors. In addition, it provides a paradigm for how transcriptional regulation may modulate the ciliogenesis pathway to give rise to structurally and functionally specialised ciliary dendrites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.