ArticlePloS one2011
Transcriptomics of the bed bug (Cimex lectularius).
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Bed bugs and possible transmission of human pathogens: a systematic review.Archives of dermatological research · 2016Pooled it
- Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.Pest management science · 2025Article
- Phylogeny and evolution of hemipteran insects based on expanded genomic and transcriptomic data.BMC biology · 2024Article
- De novo transcriptome assembly, annotation and SSR mining data of Hellula undalis (Fabr.) (Lepidoptera: Pyralidae), the cabbage webworm.Journal, genetic engineering & biotechnology · 2024Article
- Transcriptomic Response to Pyrethroid Treatment in Closely Related Bed Bug Strains Varying in Resistance.Genome biology and evolution · 2024Article
- Article
- Resistance to Fipronil in the Common Bed Bug (Hemiptera: Cimicidae).Journal of medical entomology · 2021Article
- Transcriptome analysis unravels RNAi pathways genes and putative expansion of CYP450 gene family in cotton leafhopper Amrasca biguttula (Ishida).Molecular biology reports · 2021Article
- Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany.International journal for parasitology. Drugs and drug resistance · 2020Article
- Comparative Analysis of Chitin SynthaseA dsRNA Mediated RNA Interference for Management of Crop Pests of Different Families of Lepidoptera.Frontiers in plant science · 2020Article
- Transcriptome analysis of the almond moth, Cadra cautella, female abdominal tissues and identification of reproduction control genes.BMC genomics · 2019Article
- A systemic study of indoxacarb resistance in Spodoptera litura revealed complex expression profiles and regulatory mechanism.Scientific reports · 2019Article
- Lack of influence by endosymbiont Wolbachia on virus titer in the common bed bug, Cimex lectularius.Parasites & vectors · 2019Article
- Uncovering the hidden cost of bed bugs.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Transcriptomic Analysis of Aedes aegypti in Response to Mosquitocidal Bacillus thuringiensis LLP29 Toxin.Scientific reports · 2018Article
- Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae).Parasites & vectors · 2017Review
- Functional characterization of Aquaporin-like genes in the human bed bug Cimex lectularius.Scientific reports · 2017Article
- Identification and expression of cuticular protein genes based on Locusta migratoria transcriptome.Scientific reports · 2017Article
- Transcriptome Analysis and Identification of Major Detoxification Gene Families and Insecticide Targets in Grapholita Molesta (Busck) (Lepidoptera: Tortricidae).Journal of insect science (Online) · 2017Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBed bugs (Cimex lectularius) are blood-feeding insects poised to become one of the major pests in households throughout the United States. Resistance of C. lectularius to insecticides/pesticides is one factor thought to be involved in its sudden resurgence. Despite its high-impact status, scant knowledge exists at the genomic level for C. lectularius. Hence, we subjected the C. lectularius transcriptome to 454 pyrosequencing in order to identify potential genes involved in pesticide resistance. METHODOLOGY AND PRINCIPAL
findingsUsing 454 pyrosequencing, we obtained a total of 216,419 reads with 79,596,412 bp, which were assembled into 35,646 expressed sequence tags (3902 contigs and 31744 singletons). Nearly 85.9% of the C. lectularius sequences showed similarity to insect sequences, but 44.8% of the deduced proteins of C. lectularius did not show similarity with sequences in the GenBank non-redundant database. KEGG analysis revealed putative members of several detoxification pathways involved in pesticide resistance. Lamprin domains, Protein Kinase domains, Protein Tyrosine Kinase domains and cytochrome P450 domains were among the top Pfam domains predicted for the C. lectularius sequences. An initial assessment of putative defense genes, including a cytochrome P450 and a glutathione-S-transferase (GST), revealed high transcript levels for the cytochrome P450 (CYP9) in pesticide-exposed versus pesticide-susceptible C. lectularius populations. A significant number of single nucleotide polymorphisms (296) and microsatellite loci (370) were predicted in the C. lectularius sequences. Furthermore, 59 putative sequences of Wolbachia were retrieved from the database.
conclusionsTo our knowledge this is the first study to elucidate the genetic makeup of C. lectularius. This pyrosequencing effort provides clues to the identification of potential detoxification genes involved in pesticide resistance of C. lectularius and lays the foundation for future functional genomics studies.
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