ArticlePloS one2011
Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 116 citations in OpenAlex.
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- Inhibiting Staphylococcus aureus Virulence Factors: Advances in Traditional Chinese Medicines and Active Compounds.Current microbiology · 2025Review
- Biomass Potential of Alkaline-PretreatedJournal of applied glycoscience · 2025Article
- Antibacterial Effects of Essential Oils onPharmaceuticals (Basel, Switzerland) · 2024Article
- Norwogonin aids in fighting MRSA-induced pneumonia by targeting agrAWorld journal of microbiology & biotechnology · 2024Article
- A comprehensive review on nutritional, nutraceutical, and industrial perspectives of perilla (Heliyon · 2024Review
- Applying quantitative spatial phenotypes analysis to the investigation of peltate glandular trichomes development pattern in Perilla frutescens.Plant methods · 2023Article
- Applications ofAntioxidants (Basel, Switzerland) · 2023Review
- Regulatory and Enterotoxin Gene Expression and Enterotoxins Production inInternational journal of molecular sciences · 2022Article
- Recent advances to combat ESKAPE pathogens with special reference to essential oils.Frontiers in microbiology · 2022Review
- Comparison of Antivirulence Activities of Black Ginseng against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- RNA-seq analysis of antibacterial mechanism ofPeerJ · 2021Article
- The antibacterial activity and toxin production control of bee venom in mouse MRSA pneumonia model.BMC complementary medicine and therapies · 2020Article
- Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline.AMB Express · 2019Article
- Combination effects of baicalin with levofloxacin against biofilm-related infections.American journal of translational research · 2019Article
- Ethnomedicinal, Phytochemical and Pharmacological Investigations ofMolecules (Basel, Switzerland) · 2018Review
- Genetic and Virulent Difference Between Pigmented and Non-pigmentedFrontiers in microbiology · 2018Article
- Supplemental thymol and carvacrol increases ileum Lactobacillus population and reduces effect of necrotic enteritis caused by Clostridium perfringes in chickens.Scientific reports · 2017Article
- Impact of thyme powder (Thymus vulgaris L.) supplementation on gene expression profiles of cytokines and economic efficiency of broiler diets.Environmental science and pollution research international · 2017Article
- Antimicrobial Potential of Thiodiketopiperazine Derivatives Produced by Phoma sp., an Endophyte of Glycyrrhiza glabra Linn.Microbial ecology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathogenicity of staphylococcus aureus is dependent largely upon its ability to secrete a number of virulence factors, therefore, anti-virulence strategy to combat S. aureus-mediated infections is now gaining great interest. It is widely recognized that some plant essential oils could affect the production of staphylococcal exotoxins when used at subinhibitory concentrations. Perilla [Perilla frutescens (L.) Britton], a natural medicine found in eastern Asia, is primarily used as both a medicinal and culinary herb. Its essential oil (perilla oil) has been previously demonstrated to be active against S. aureus. However, there are no data on the influence of perilla oil on the production of S. aureus exotoxins. METHODOLOGY/PRINCIPAL
findingsA broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of perilla oil against S. aureus strains. Hemolysis, tumour necrosis factor (TNF) release, Western blot, and real-time RT-PCR assays were performed to evaluate the effects of subinhibitory concentrations of perilla oil on exotoxins production in S. aureus. The data presented here show that perilla oil dose-dependently decreased the production of α-toxin, enterotoxins A and B (the major staphylococcal enterotoxins), and toxic shock syndrome toxin 1 (TSST-1) in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). CONCLUSIONS/SIGNIFICANCE: The production of α-toxin, SEA, SEB, and TSST-1 in S. aureus was decreased by perilla oil. These data suggest that perilla oil may be useful for the treatment of S. aureus infections when used in combination with β-lactam antibiotics, which can increase exotoxins production by S. aureus at subinhibitory concentrations. Furthermore, perilla oil could be rationally applied in food systems as a novel food preservative both to inhibit the growth of S. aureus and to repress the production of exotoxins, particularly staphylococcal enterotoxins.
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